Serum uric acid is associated with disease severity and may predict clinical outcome in patients of pulmonary arterial hypertension secondary to connective tissue disease in Chinese: a single-center retrospective study

Table 1 Baseline Characteristic of normouricemia and hyperuricemia groups

	Hyperuricemia group(n = 23)	Normouricemia group (n = 27)	p
Gender (women/ men)	21/2	26/1
Age, Y	40.17 ± 3.11	38.22 ± 2.36
SLE	7 (14%)	13 (26%)
SS	8 (16%)	6 (12%)
CTD	4 (8%)	0
SSc	3 (6%)	2 (4%)
SLE/SS	1 (2%)	1 (2%)
MCTD	0	5 (10%)
Body Mass Index, kg/m^2	22.0 ± 0.1	22.28 ± 0.71	ns
WHO functional class, III-IV/I-II	15/8	17/10	ns
6MWD, m	390.8 ± 30.85	404.1 ± 27.93	ns
UA, μmol/L	467.0 ± 19.67	277.7 ± 10.02	ns
Creatinine, μmol/L	63.24 ± 3.02	63.14 ± 5.33	ns
NT-pro BNP, pg/ml	2368 ± 662.80	1270 ± 465.80	ns
Treatment with diuretics, yes/no	5/18	6/21	ns
echocardiography
PASP, mmHg	83.13 ± 4.93	74.19 ± 3.40	ns
TAPSE, cm	1.53 ± 0.11	2.15 ± 0.36	ns
right heart catheterization
Rap, mmHg	8.13 ± 1.22	6.00 ± 0.91	ns
mPAP, mmHg	45.43 ± 2.41	45.70 ± 2.09	ns
PAWP, mmHg	8.91 ± 0.76	8.58 ± 0.77	ns
CO, L/min	3.75 ± 0.37	5.19 ± 0.51	0.029
CI, L/min/m²	2.31 ± 0.24	3.15 ± 0.28	0.028
PVR, Wood U	12.77 ± 1.85	8.50 ± 1.93	0.0244
SVO2, %	57.81 ± 2.51	65.13 ± 1.97	0.029

Numerical values were expressed as mean ± standard error. Comparisons between two groups were calculated by Student’s unpaired t test or Fisher’s exact test
SLE systemic lupus erythematosus, SS Sjogren’s syndrome, CTD connective tissue disease, SSc systematic sclerosis, SLE/SS systemic lupus erythematosus /Sjogren’s syndrome, MCTD mixed CTD (MCTD) was defined by Sharp criteria, WHO functional class World Health Organization Cardiac Function Classification, 6MWD 6-min walking distance, NT-pro BNP N-terminal pro-B-type natriuretic peptide, PASP pulmonary artery systolic pressure, TAPSE systolic displacement of tricuspid annulus, RAP right atrial pressure, mPAP mean pulmonary arterial pressure, PAWP pulmonary artery wedge pressure, CO cardiac output, CI cardiac index, PVR pulmonary vascular resistance, SVO2 mixed venous oxygen saturation

ISSN: 1471-2466