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Table 2 List of proteins with altered expression in COPD patients vs the controls, as per the MALDI sequencing analysis

From: Elevated serum matrix metalloprotease (MMP-2) as a candidate biomarker for stable COPD

S. No. Name of the identified proteins Fold change Predicted function
1 Preg. Zone Protein (PZP) −3.6 Protease inhibitor, able to inhibit all four classes of proteases
2 α-2 Macroglobulin(A2MG) −2.5 Protease inhibitor, able to inhibit all four classes of proteases
3 Peptidase Inhibitor (PI16) −2.3 Serine Protease Inhibitor
4 Serotransferrin TRFE_Human) −2.0 To prevent oxidative damage
5 Cytokine suppressor (SOCS-3) 3.1 SOCS-3; Suppressor of cytokine signaling. SOCS3 involved in the negative regulation of cytokines.
6 Carboxy peptidase B2,(CBPB2) 2.4 Carboxy peptidase (cleave basic amino residues), plays a major role in the breakdown of the extracellular matrix
7 Matrix Metallo
Protease −2 (MMP-II)
2.6 MMP-2 or Gelatinase A or type IV Collagenase, breakdown extracellular matrix
8 Human Leukocyte Elastase (HLE) 2.8 Serine Protease that hydrolyzes many proteins in addition to Elastin