Skip to main content
Fig. 1 | BMC Pulmonary Medicine

Fig. 1

From: A phase Ib/IIa, randomised, double-blind, multicentre trial to assess the safety and efficacy of expanded Cx611 allogeneic adipose-derived stem cells (eASCs) for the treatment of patients with community-acquired bacterial pneumonia admitted to the intensive care unit

Fig. 1

Adipose-derived mesenchymal stem cells are sampled from human adipose tissue and expanded ex vivo. Their immunomodulatory and anti-microbial effects are utilised for the treatment of sCABP. eASC MoA: eASCs modulate inflammation through the generation of regulatory immune cells (e.g. Tregs, M2 Mph) by reducing pro-inflammatory cytokines (e.g. TNFα, IL-6, IL-8); increasing the release of the anti-inflammatory cytokine IL-10; inhibiting apoptosis of immune cells; and reducing lymphocyte, neutrophil and macrophage infiltration. eASCs also have anti-microbial effects as they release peptides with antimicrobial properties (e.g. LL-37) and increase the phagocytic capacity of monocytes, macrophages and neutrophils. Due to these properties, eASCs can reduce organ injury and increase functionality, thus conferring a therapeutic benefit [11]. eASC expanded adipose-derived mesenchymal stem cell, IFN interferon, IL interleukin, KGF keratinocyte growth factor, M2 Mph macrophages, MoA mode of action, sCABP severe community-acquired bacterial pneumonia, Treg regulatory T cell, TNFα tumour necrosis factor alpha

Back to article page