Fig. 3

a Study design for SEPCELL. A phase Ib/IIa, randomised, multicentre, double-blind, placebo-controlled study to assess the safety, tolerability and efficacy of eASCs (Cx611) administered intravenously, in addition to SoC therapy, to patients with sCABP. An amendment to the study protocol extended the follow-up period to 2 years (Table 2). b Trial flow diagram for SEPCELL. BL baseline, CABP community-acquired bacterial pneumonia, SPIRIT Standard Protocol Items: Recommendations for Interventional Trials, eASC expanded allogeneic adipose-derived mesenchymal stem cell, IV intravenous, SAE serious adverse event, sCABP severe community-acquired bacterial pneumonia, SoC standard of care. *From initiation of mechanical ventilation and/or vasopressors administration; **Screening procedures will start as soon as informed consent is signed