Table 1 Clinical details of the 23 pulmonary benign metastasizing leiomyomas in Peking Union Medical College Hospital series
From: Pulmonary benign metastasizing leiomyomas: a case series of 23 patients at a single facility
Case No. | Time to Diagnosis From Gynecologic Surgery (y) | Symptoms | Radiographic Findings | Surgical Procedure for Diagnosis | Immunohistochemistry | Follow up |
|---|---|---|---|---|---|---|
1 | N/A | Cough | Right lower lobe nodule, single | Thoracotomy, resection of the right middle segment of the lung | SMA(+), Desmin(+), S-100(−) | 14 year, CR |
2 | N/A | Cough | Right pulmonary hilum nodule, single | Thoracotomy, right upper lobe resection | N/A | 18 years, CR |
3 | 2 | No | Right upper lobe multiple nodules | Thoracotomy, wedge resection of right upper lobe | N/A | 17 years, SD |
4 | 11 | No | B/L multiple nodules | VATS, wedge resection | SMA(+), Desmin(+),ER(+/−), PR(+), S-100(−) | 11 years, SD |
5 | N/A | Cough | Left main bronchus nodule, single | Thoracotomy, resection of left lung | SMA(+), Desmin(+), S-100(−), Ki-67 < 1% | 8 years, CR |
6 | 14 | Chest pain | B/L multiple nodules | VATS, wedge resection of left lower lobe | ER(++), PR(++), Ki-67 (1%) | 8 years, SD |
7 | N/A | No | Left upper lobe nodule, single | VATS, resection of left upper lobe | SMA(++), Desmin(+++), S-100(−) | 9.5 years, CR |
8 | 11 | Short of breath | B/L multiple nodules | Biopsy | CD34(−), CD117(−), Desmin(+), SMA(+), Ki-67(1%), S-100(−) | 3 years, PD |
9 | 10 | Short of breath | B/L multiple nodules | VATS, wedge resection of left lower lobe | ER(+), PR(+),Desmin(+), SMA(+), Ki-67 (3%) | 1 year, SD |
10 | 7 | No | B/L multiple nodules | Biopsy | ER(+), PR(+), KI-67 < 1% | 9 years, SD |
11 | 10 | Cough | B/L multiple nodules | Biopsy | SMA(+), ER(+), PR(+), Desmin(+), Ki-67(3%), CD34(−), S-100(−) | 1.5 year, SD |
12 | 2 | Short of breath | B/L multiple cysts, pneumothorax | VATS, wedge resection of left upper lobe | ER(+), PR(+),Desmin(+), Vimentin(+) | 1.5 year, SD |
13 | 14 | No | B/L multiple nodules | Biopsy | N/A | 17 months, PR |
14 | 6 | No | B/L multiple nodules | Biopsy | N/A | 4 years, PD |
15 | 9 | No | B/L multiple nodules | Biopsy | SMA(+), Desmin(+),BCL-2(+),Ki-67 (3%) | 2 years, PR |
16 | N/A | Cough | B/L multiple nodules | VATS, right upper lobe resection | N/A | 19 months, SD |
17 | 5 | No | B/L multiple nodules | VATS, resection of left pulmonary mass | ER(+++), PR(+++), Desmin(+++), Ki-67<1% | 11 year, PR |
18 | 14 | Backache | B/L multiple nodules | Biopsy | SMA(+), Desmin(+), Caldesmon(+), Ki-67 < 1% | 2 months, not included |
19 | N/A | Bloating | B/L multiple nodules | Biopsy | N/A | 6 months, not included |
20 | N/A | No | B/L multiple nodules | Biopsy | SMA(+), Desmin(+), ER(+), PR(+), Ki-67 (2%) | 12 years, SD |
21 | 12 | No | B/L multiple nodules | Biopsy | ER(+),PR(+),SMA(+),S-100(−) | 6 months, not included |
22 | 14 | Cough | B/L multiple nodules | VATS | SMA(+),Desmin(+), ER(+), PR(+) | 2 months, not included |
23 | 15 | Cough | B/L multiple nodules | Biopsy | SMA(+),Desmin(+), ER(++), PR(+), Ki-67(1%) | 4 months, not included |