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Table 4 Univariate and multivariate analyses of predictive factors for successful HFNC

From: Application of high-flow nasal cannula in hypoxemic patients with COVID-19: a retrospective cohort study

Variable

Odds ratio

95% CI

p value

Univariate analysis of predictive factors of the outcome of HFNC

 Age, years

0.871

0.819–0.926

<0.001

 Sex, male

0.400

0.178–0.899

0.027

 Comorbidities

0.700

0.313–1.565

0.385

 Smoking, current or former

1.086

0.297–3.973

0.901

 LYM (× 109/ L; normal range 1.1–3.2)

1.045

0.235–4.657

0.954

 D–D (ug/ml; normal range 0.0–0.5)

1.001

0.947–1.058

0.974

 CRP (mg/L; normal range 0.0–5.0)

0.999

0.988–1.011

0.922

 PaO2/FiO2 at HFNC application

1.002

0.985–1.018

0.830

 PSI

0.931

0.903–0.960

<0.001

 APACHE-II

0.822

0.710–0.951

0.008

 SOFA

0.501

0.338–0.744

0.001

 6h ROX index >5.55, yes

8.643

3.342–22.354

<0.001

Multivariate analysis of predictive factors of the outcome of HFNC

 Age, years

0.837

0.745–0.940

0.003

 Sex, male

0.172

0.038–0.790

0.024

 PSI

1.004

0.939–1.074

0.903

 APACHE-II

1.166

0.858–1.585

0.326

 SOFA

0.389

0.203–0.745

0.004

 6h ROX index >5.55, yes

17.821

3.741–84.903

<0.001

  1. HFNC high-flow nasal cannula oxygen therapy, LYM lymphocyte number, D-D, D-dimer, CRP c-reaction protein, PSI pneumonia severity index, APACHE-II Acute Physiology and Chronic Health Evaluation II, SOFA Sepsis-related Organ failure Assessment, ROX index Respiratory rate-oxygenation index