Table 1 Schedule of the assessments for each patient during the study

Informed consent

x

Eligibility assessment

x

x

Randomisation

x

Medical history

x

Comorbidities

Prior medications

APACHE II score

x

SOFA score

x

x

x

x

x

WHO disease progression scale

x

x

x

CRP

x

x

x

x

x

Viral load (NP or tracheal PCR)

Clinical frailty scale

x

Concomitant drugs against SARS-CoV-2

x

x

x

x

x

x

Biological findings

x^a

x^b

x^b

x ^b

x^b

24 h-diuresis

x

x

x

x

x

Serum sample for central analysis

x

x

x

x

Mechanical ventilation

x

x

x

x

x

Renal replacement therapy

x

x

x

x

x

Vasoactive drugs

x

x

x

x

x

ECMO

x

x

x

x

x

Nosocomial infections

x

x

x

x

x

Iatrogenic events

x

x

x

x

x

Adverse events & Serious adverse event

x

x

x

x

x

ADL scale

x

x

x

Anxiety-depression scale

x

x

EQ-5D-5L scale

x

x

x