Low arterial oxygen partial pressure induces pulmonary thrombocytopenia in patients and a mouse model

BMC Pulmonary Medicine

Table 1 Baseline Characteristics of Patients with Infectious Diseases (N = 16,923)

Variables	Thrombocytopenia (n = 1468)	Normal platelet (n = 15,455)	p Value
Demographic characteristics
Age, years	57.94 ± 23.62	58.57 ± 23.81	0.34
Sex, female, n (%)	876(59.7)	8771(56.8)	0.03*
Infection location, n (%)			< 0.001*
Lung	1171(9.8)	10,770(90.2)
Urinary tract	213(6.4)	3114(93.6)
Intestinal tract	53(5.0)	1000(95.0)
Skin soft-tissue	31(5.1)	571(94.9)
Biochemical indexes
WBC (*10⁹/L)	9.92 ± 3.99	10.00 ± 4.09	0.54
HB (g/L)	128.46 ± 33.44	127.45 ± 33.42	0.27
PLT (*10⁹/L)	70.33 ± 23.53	211.32 ± 80.26	< 0.001*
TBil (μmol/L)	19.94 ± 8.62	19.81 ± 8.53	0.58
AST (U/L)	36.07 ± 13.60	36.49 ± 13.66	0.26
ALT (U/L)	42.17 ± 18.80	41.84 ± 19.08	0.54
Creatinine (mmol/l)	93.86 ± 30.21	93.30 ± 30.18	0.49
CRP (mg/L)	50.48 ± 48.53	51.21 ± 49.21	0.67
PCT (ng/ml)	0.35 ± 0.21	0.25 ± 0.35	0.60
Medical history, n (%)
Hypertension	453 (30.9)	5512 (35.7)	< 0.001*
Diabetes	220 (15.0)	2613 (16.9)	0.06

Date were presented as mean ± (SD) or n(%).The physiological variables were collected within the first 24 h of admission. ^*Significant differences (P < 0.05)
WBC white blood cell, HB haemoglobin, PLT platelet, TBil total bilirubin, AST aspertate aminotransferase, ALT alanine aminotransferase, CRP C-reactive protein, PCT procalcitonin

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