Low arterial oxygen partial pressure induces pulmonary thrombocytopenia in patients and a mouse model

BMC Pulmonary Medicine

Table 3 Analysis on Risk Factors Associated with Thrombocytopenia in Patients with Pulmonary Infection (N = 11,941)

Variables	Thrombocytopenia (n = 1171)	Normal platelet (n = 10,770)	Univariate Analysis			Multivariate Analysis
Variables	Thrombocytopenia (n = 1171)	Normal platelet (n = 10,770)	OR	95%CI	P value	OR	95% CI	P value
Age, years (SD)	57.79 ± 24.06	58.76 ± 23.74	0.99	0.99–1.00	0.19
Sex, female, n (%)	454 (38.8)	4356 (40.4)	0.93	0.82–1.06	0.27
Biochemical indexes
WBC (× 10⁹/L)	9.90 ± 3.98	9.96 ± 4.08	0.99	0.98–1.01	0.63
HB (g/L)	126.75 ± 33.31	127.81 ± 33.49	0.98	0.98–0.99	0.30
CRP (mg/L)	49.54 ± 48.18	51.23 ± 49.29	0.99	0.98–1.00	0.26
PCT (ng/ml)	0.25 ± 0.15	0.31 ± 0.10	0.98	0.97–1.99	0.87
CPIS scores	7.25 ± 2.16	7.00 ± 2.99	1.25	1.18–1.32	< 0.001^*	1.24	1.17–1.31	< 0.001^*
Medical history, n (%)
Hypertension	392 (33.5)	4385 (40.7)	0.73	0.65–0.83	< 0.001^*	0.74	0.65–0.85	< 0.001^*
Diabetes	177 (15.1)	1798 (16.7)	0.89	0.75–1.05	0.17
RF	101 (8.6)	574 (5.3)	1.68	1.35–2.09	< 0.001^*	1.59	1.27–1.98	< 0.001^*
COPD	78 (6.7)	519 (4.8)	1.24	0.91–1.68	0.17

Date were presented as mean ± (SD) or n(%)
WBC white blood cell, HB haemoglobin, CRP C-reactive protein, PCT procalcitonin, CPIS clinical lung infection score, RF respiratory failure, COPD chronic obstructive lung disease, OR odds ratio, CI confidence interval
*Significant differences (P < 0.05)

ISSN: 1471-2466