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Table 3 GINA 2012- and 2018-defined control level at Week 12 in patients using ICS/LABA with and without LTRA

From: Post hoc analysis of initial treatments and control status in the INITIAL study: an observational study of newly diagnosed patients with asthma

Baseline asthma severity

Control status at Week 12

GINA 2012

GINA 2018

ICS/LABA + LTRA, n (%)

ICS/LABA, n (%)

Total, n (%)

ICS/LABA + LTRA, n (%)

ICS/LABA, n (%)

Total, n (%)

Intermittent

Controlled

32 (78.1)

32 (80.0)

64 (79.0)

46 (86.8)

47 (95.9)

93 (91.2)

Partly controlled

9 (22.0)

8 (20.0)

17 (21.0)

7 (13.2)

2 (4.1)

9 (8.8)

Uncontrolled

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

Total

41

40

81

53

49

102

Mild

Controlled

122 (86.5)

121 (85.8)

243 (86.2)

167 (86.1)

178 (93.2)

345 (89.6)

Partly controlled

18 (12.8)

19 (13.5)

37 (13.1)

24 (12.4)

11 (5.8)

35 (9.1)

Uncontrolled

1 (0.7)

1 (0.7)

2 (0.7)

3 (1.6)

2 (1.1)

5 (1.3)

Total

141

141

282

194

191

385

Moderate

Controlled

215 (78.5)

149 (71.3)

364 (75.4)

325 (82.1)

255 (85.3)

580 (83.5)

Partly controlled

54 (19.7)

58 (27.8)

112 (23.2)

61 (15.4)

43 (14.4)

104 (15.0)

Uncontrolled

5 (1.8)

2 (1.0)

7 (1.5)

10 (2.5)

1 (0.3)

11 (1.6)

Total

274

209

483

396

299

695

Severe

Controlled

558 (59.6)

338 (61.8)

896 (60.4)

921 (71.9)

581 (77.6)

1502 (74.0)

Partly controlled

339 (36.2)

185 (33.8)

524 (35.3)

312 (24.4)

150 (20.0)

462 (22.8)

Uncontrolled

40 (4.3)

24 (4.4)

64 (4.3)

48 (3.8)

18 (2.4)

66 (3.3)

Total

937

547

1484

1281

749

2030

  1. GINA Global Initiative for Asthma, ICS inhaled corticosteroid, LABA long-acting β2 agonist, LTRA leukotriene receptor antagonist