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Table 2 Association between CHCHD2 and HIF-1α protein expressions and clinicopathological features in NSCLC patients

From: CHCHD2 is a potential prognostic factor for NSCLC and is associated with HIF-1a expression

Clinicopathologic features

n = 209

CHCHD2 expression

HIF-1α expression

+

++

+++

Z

P-value

+

++

+++

Z

P-value

Gender

 Male

157

11

63

70

12

−1.478

0.139

8

39

94

16

−1.371

0.170

 Female

52

0

18

29

5

1

9

36

6

Age (years)

 ≥62

107

7

37

56

7

−0.573

0.567

5

23

66

13

−0.599

0.549

 < 62

102

4

45

45

8

4

25

64

9

Smoking

 Yes

132

10

54

61

7

−2.001

0.045

8

36

74

14

−2.114

0.035

 No

77

1

28

40

8

1

12

56

8

Tumor position

 Periphery type

73

3

34

31

5

−1.024

0.306

4

14

50

5

−0.162

0.871

 Central type

136

8

48

70

10

5

34

80

17

Tumor size (cm)

 >5

109

5

27

69

8

−3.916

0.000

5

23

68

13

−0.692

0.489

 ≤5

100

6

55

32

7

4

25

62

9

Tumor category

 Adenocarcinoma

82

2

29

44

7

−1.738

0.082

2

12

59

9

−2.213

0.027

 Squamous caner

127

9

53

57

8

7

36

71

13

Differentiation degree

 Well/ Moderate

152

8

66

70

8

−2.122

0.034

7

42

91

12

−2.939

0.003

 Poor

57

3

16

31

7

2

6

39

10

TNM Stage

 Ia-IIa

116

9

68

38

1

−7.279

0.000

8

33

66

9

−3.093

0.002

 IIb -IIIb

93

2

14

63

14

1

15

64

13

Lymph metastasis

 metastasis

116

4

33

65

14

−4.468

0.000

3

20

77

16

−2.967

0.003

 Non-metastasis

93

7

49

36

1

6

28

53

6