Table 4 The correlation of CHCHD2 with HIF-1α protein expression in NSCLC
From: CHCHD2 is a potential prognostic factor for NSCLC and is associated with HIF-1a expression
Group | CHCHD2 | HIF-1α | ||||||
|---|---|---|---|---|---|---|---|---|
– | + | ++ | +++ | rs | P-value | |||
NSCLC | – | 7 | 2 | 2 | 0 | 0.526 | 0.000 | |
+ | 1 | 35 | 43 | 3 | ||||
++ | 1 | 11 | 80 | 9 | ||||
+++ | 0 | 0 | 5 | 10 | ||||
Histological type | ||||||||
Adenocarcinoma | – | 1 | 0 | 1 | 0 | 0.447 | 0.000 | |
+ | 1 | 9 | 18 | 1 | ||||
++ | 0 | 4 | 37 | 4 | ||||
+++ | 0 | 0 | 3 | 4 | ||||
Squamous caner | – | 6 | 2 | 1 | 0 | 0.548 | 0.000 | |
+ | 0 | 26 | 25 | 2 | ||||
++ | 1 | 8 | 43 | 5 | ||||
+++ | 0 | 0 | 2 | 6 | ||||
Differentiation | ||||||||
High/ Moderate | – | 5 | 2 | 1 | 0 | 0.550 | 0.000 | |
+ | 1 | 31 | 34 | 0 | ||||
++ | 1 | 9 | 54 | 6 | ||||
+++ | 0 | 0 | 2 | 6 | ||||
Poor | – | 2 | 0 | 1 | 0 | 0.380 | 0.004 | |
+ | 0 | 4 | 9 | 3 | ||||
++ | 0 | 2 | 26 | 3 | ||||
+++ | 0 | 0 | 3 | 4 | ||||
Lymph node metastasis | ||||||||
Lymph metastasis | – | 2 | 1 | 1 | 0 | 0.515 | 0.000 | |
+ | 1 | 12 | 18 | 2 | ||||
++ | 0 | 7 | 53 | 5 | ||||
+++ | 0 | 0 | 5 | 9 | ||||
Non-Lymph metastasis | – | 5 | 1 | 1 | 0 | 0.494 | 0.000 | |
+ | 0 | 23 | 25 | 1 | ||||
++ | 1 | 4 | 27 | 4 | ||||
+++ | 0 | 0 | 0 | 1 | ||||