Table 2 Blood cells and inflammatory cell ratios according to sputum inflammatory phenotype
From: Blood cell for the differentiation of airway inflammatory phenotypes in COPD exacerbations
All | Neutrophilic (n = 152) | Eosinophilic (n = 8) | Mixed granulocytic (n = 104) | Paucigranulocytic (n = 23) | P-value | |
|---|---|---|---|---|---|---|
White blood cell (× 109/L) | 7.6 (5.9–10.5) | 8.2 (6.2–11) | 6.15 (5.05–6.58) | 6.4 (5.5–8.6)# | 7.95 (5.75–11.5) | < 0.001 |
Neutrophils (× 109/L) | 5.5 (4.18–8.2) | 6.1 (4.4–8.9) | 4 (2.83–4.3) | 4.7 (3.68–6.25)# | 5.85 (4.25–8.95) | < 0.001 |
Eosinophils (× 109/L) | 0.1 (0–0.1) | 0 (0–0.1) | 0.25 (0.13–0.3)*# | 0.1 (0–0.2)*# | 0 (0–0.1) | < 0.001 |
Leukocytes (×109/L) | 1.2 (0.8–1.8) | 1.2 (0.7–1.7) | 1.3 (1.05–2.3) | 1.3 (1–1.73)# | 1.3 (1.05–1.9) | =0.022 |
Monocytes (×109/L) | 0.4 (0.3–0.6) | 0.4 (0.3–0.7) | 0.45 (0.4–0.73) | 0.4 (0.3–0.6) | 0.4 (0.2–0.6) | =0.079 |
Neutrophils % | 76.3 (67.28–83.53) | 78.6 (70.45–84.75) | 63.95 (51–70.15) | 70.9 (62.68–78.55)# | 73.9 (63.63–84.38) | < 0.001 |
Eosinophils % | 0.5 (0.2–1.73) | 0.3 (0.2–0.95) | 4.3 (1.88–6.5)*# | 1.6 (0.4–3.03)*# | 0.3 (0.18–1.7) | < 0.001 |
Leukocytes % | 16.2 (10.78–23.6) | 14.7 (9.45–21.6) | 25.7 (19.3–31.73) | 19.7 (14.1–26.63)# | 18.35 (11.1–27.7) | < 0.001 |
Monocytes % | 5.4 (3.8–7.3) | 5.4 (3.7–7.45) | 7.2 (5.93–9.88) | 5.6 (4.5–7.13) | 3.85 (3.33–7) | =0.091 |
Blood NLR | 4.72 (2.8–7.68) | 5.38 (3.2–9) | 2.65 (1.63–3.68) | 3.6 (2.45–5.63)# | 3.81 (2.22–7.89) | < 0.001 |
Blood ELR | 0.03 (0–0.1) | 0 (0–0.08) | 0.14 (0.24–0.08)*# | 0.09 (0–0.16)*# | 0 (0–0.07) | < 0.001 |
Blood ENR | 0.01 (0–0.03) | 0 (0–0.02) | 0.06 (0.03–0.12)*# | 0.02 (0–0.06)*# | 0 (0–0.02) | < 0.001 |
Blood EMR | 0.07 (0–0.33) | 0 (0–0.21) | 0.45 (0.24–0.73)*# | 0.25 (0–0.5)*# | 0 (0–0.31) | < 0.001 |
Blood NMR | 13.27 (9.33–20.28) | 14 (9.76–21.93) | 8.3 (4.9–10.44) | 12 (8.92–16.64) | 18.5 (9.7–26) | =0.004 |
Blood MLR | 0.33 (0.22–0.5) | 0.37 (0.25–0.6) | 0.33 (0.29–0.37) | 0.29 (0.2–0.42)# | 0.25 (0.15–0.41)# | < 0.001 |