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Table 2 Blood cells and inflammatory cell ratios according to sputum inflammatory phenotype

From: Blood cell for the differentiation of airway inflammatory phenotypes in COPD exacerbations

 AllNeutrophilic (n = 152)Eosinophilic (n = 8)Mixed granulocytic (n = 104)Paucigranulocytic (n = 23)P-value
White blood cell (× 109/L)7.6 (5.9–10.5)8.2 (6.2–11)6.15 (5.05–6.58)6.4 (5.5–8.6)#7.95 (5.75–11.5)< 0.001
Neutrophils (× 109/L)5.5 (4.18–8.2)6.1 (4.4–8.9)4 (2.83–4.3)4.7 (3.68–6.25)#5.85 (4.25–8.95)< 0.001
Eosinophils (× 109/L)0.1 (0–0.1)0 (0–0.1)0.25 (0.13–0.3)*#0.1 (0–0.2)*#0 (0–0.1)< 0.001
Leukocytes (×109/L)1.2 (0.8–1.8)1.2 (0.7–1.7)1.3 (1.05–2.3)1.3 (1–1.73)#1.3 (1.05–1.9)=0.022
Monocytes (×109/L)0.4 (0.3–0.6)0.4 (0.3–0.7)0.45 (0.4–0.73)0.4 (0.3–0.6)0.4 (0.2–0.6)=0.079
Neutrophils %76.3 (67.28–83.53)78.6 (70.45–84.75)63.95 (51–70.15)70.9 (62.68–78.55)#73.9 (63.63–84.38)< 0.001
Eosinophils %0.5 (0.2–1.73)0.3 (0.2–0.95)4.3 (1.88–6.5)*#1.6 (0.4–3.03)*#0.3 (0.18–1.7)< 0.001
Leukocytes %16.2 (10.78–23.6)14.7 (9.45–21.6)25.7 (19.3–31.73)19.7 (14.1–26.63)#18.35 (11.1–27.7)< 0.001
Monocytes %5.4 (3.8–7.3)5.4 (3.7–7.45)7.2 (5.93–9.88)5.6 (4.5–7.13)3.85 (3.33–7)=0.091
Blood NLR4.72 (2.8–7.68)5.38 (3.2–9)2.65 (1.63–3.68)3.6 (2.45–5.63)#3.81 (2.22–7.89)< 0.001
Blood ELR0.03 (0–0.1)0 (0–0.08)0.14 (0.24–0.08)*#0.09 (0–0.16)*#0 (0–0.07)< 0.001
Blood ENR0.01 (0–0.03)0 (0–0.02)0.06 (0.03–0.12)*#0.02 (0–0.06)*#0 (0–0.02)< 0.001
Blood EMR0.07 (0–0.33)0 (0–0.21)0.45 (0.24–0.73)*#0.25 (0–0.5)*#0 (0–0.31)< 0.001
Blood NMR13.27 (9.33–20.28)14 (9.76–21.93)8.3 (4.9–10.44)12 (8.92–16.64)18.5 (9.7–26)=0.004
Blood MLR0.33 (0.22–0.5)0.37 (0.25–0.6)0.33 (0.29–0.37)0.29 (0.2–0.42)#0.25 (0.15–0.41)#< 0.001
  1. NLR Neutrophil/lymphocyte ratio, ELR Eosinophil/lymphocyte ratio, ENR Eosinophil/neutrophil ratio, EMR Eosinophil/macrophage ratio, NMR Neutrophil/macrophage ratio, MLR Macrophage/lymphocyte ratio;
  2. According to Bonferroni principle, *P < 0.008, paucigranulocytic AECOPD is used as the comparator; #P < 0.008, Neutrophilic AECOPD is used as the comparator
  3. Data are presented as median (inter-quartile range)