Table 3 Pulmonary function test at first SAC visit compared to GIA

FVC litres pre BD

2.6/2.6 (0.7/1.3–4.0)

2.4/2.4 (0.5/1.9–3.4)

2.3/2.4 (0.4/1.6–3.1)

0.546

FVC % pre BD

97.7/98 (14.9/64–127)

93.5/94.5 (11.6/75.2–111)^$

108.5/109.2 (10.5/84.1–124)^$

0.019

FEV1 litres pre BD

1.8/1.9 (0.6/1.1–3.3)

2.1/2.0 (0.3/1.7–2.6)

1.9/2.1 (0.3/1.2–2.6)

0.300

FEV1% pre BD

78.4/81 (17.7/40–112) *

94.9/95 (5.8/86–103)

102.7/104.8 (12.13/72–121)*

0.0001

Abnormal FEV1% pre BD^#

11(48)

0

1(8)

0.007

FEV1/FVC litres pre BD

70.3/69.4 (9.5/47.7–88.2)^!

88.0/84.1 (7.9/78.1–98.4)^!

121.3/119.4 (8.1/110.3–135.2)^!

< 0.0001

FVC litres post BD

2.8/2.7 (0.8/1.3–4.1)

2.4/2.5 (0.5/1.9–3.3)

2.4/2.4 (0.4/1.7–3.2)

0.189

FVC % post BD

102.3/104 (13.22/75–124)

95.9/98.1 (9.8/82–109)^$

109.9/110.2 (8.7/90–122.3)^$

0.011

FEV1 litres post BD

2.0/2.1 (0.6/1.1–3.5)

2.2/2.2 (0.3/1.8–2.7)

2.1/2.2 (0.4/1.3–2.8)

0.458

FEV1% post BD

85.7/88 (16.7/47–117)*

99.2/99.8 (4.8/92–106)

109.6/112 (12.2/78.1–129.2)*

< 0.0001

FEV1/FVC litres post BD

73.7/73.7 (9.6/55.7–92.3)^!

89.3/90.2 (5.5/79.9–96.1)^!

87.1/89.6 (5.1/75.9–94.4)^!

< 0.0001

BDR %

11/7 [11.3/(−2)-45]

4/6 [4.3/(−1.2)-10]

7/7 (3.7/0–13)

0.187

BDR ≥12%^#

6(26)

0

1(8)

0.158

TLC%

115/111 (21/88–184)

–

–

–

TLC litres

4/4 (1/3–6)

–

–

–

RV/TLC %

157/152 (42/92–254)

–

–

–

Abnormal RV/TLC%^#

13(57)

–

–

–

n = 14

n = 7

n = 11

LCI

10.5/10.7 (2.3/7.1–13.9)^!

7.6/7.4 (1.2/6.3–9.9)^!

7.3/7.3 (1.0/5.4–9.1)^!

0.003

Abnormal LCI (%)^@

11(79)

1(14)

3(27)

0.002

FRC/body weight (mL/kg)

47/46 (15/23–76)

36/35 (10/20–50)

44/42 (14/21–72)

0.211

FeNO (ppb)**

31.7/15 (31/6–90)

31/20 (25/12–74)

24/21 (19/7–51)

0.861

Abnormal FeNO^#

8(38)

2(40)^#

2(40)^#

0.934