Table 5 Pulmonary function test first and follow-up for SAC patients stratified for intervention

FVC litres pre BD

2.6/2.1 (0.6/1.8–3.7)

3.9/3.5 (1.5/2.5–6.7)

0.0255

2.5/2.6 (0.6/1.6–3.5)

3.5/3.4 (1.2/1.4–5.3)

0.004

FVC % pre BD

88.1/86 (16.5/64–109)

106.1/110 (8.1/95–114)

0.0318

95.3/96 (9.5/81–108)

96.2/93 (9.7/81–110)

0.809

FEV1 litres pre BD

1.7/1.8 (0.5/1.1–2.5)

2.8/2.4 (1.2/1.7–4.9)

0.0258

1.7/1.7 (0.4/1.1–2.4)

2.7/2.8 (0.7/1.2–3.4)

0.0005

FEV1% pre BD

68.0/71 (19.3/40–91)

82.4/78 (15.5/59–107)

0.0787

71.2/72 (10.1/57–84)

85.4/87 (6.1/73/92)

0.004

Abnormal FEV1% pre BD

5(71)

4(57)

0.5770

6(67)

1(11)

0.016

FEV1/FVC litres pre BD

65.7/66.8 (8.8/47.6–73.4)

71.8/69.4 (4.8/67.6–80)

0.1240

67.9/67.7 (9.1/57.6–88.2)

78.0/77.6 (9.8/64.7–95.3)

0.012

FVC litres post BD

2.8/2.8 (0.6/2.1–3.9)

3.9/3.6 (1.5/2.6–6.8)

0.0295

2.6/2.7 (0.6/1.6–3.7)

3.7/3.4 (1.2/1.5–5.5)

0.004

FVC % post BD

94/91 (14.4/75–113)

108.3/109 (6.5/97/116)

0.0282

100.7/102 (9.7/85–117)

99.8/102 (10.2/84–114)

0.837

FEV1 litres post BD

1.9/1.9 (0.5/1.2–2.7)

2.9/2.7 (1.4/1.6–5.6)

0.0631

1.8/1.7 (0.4/1.2–2.5)

2.8/2.9 (0.7/1.3–4.1)

0.0007

FEV1% post BD

75.1/79 (17.2/47–94)

90/85 (18.4/66–118)

0.0952

81.1/77 (10.7/89–98)

89.8/93 (8.5/73–98)

0.009

FEV1/FVC litres post BD

68.7/71.4 (8.1/55.7–79.6)

72.2/74.3 (9.9/54–82.6)

0.5572

72.5/72.9 (10.1/58.9–92.3)

79.1/75.7 (10.6/65.1–98.3)

0.037

BDR %

13/6 (16/3–45)

13/12 (7/3–23)

> 0.9999

9/9 [9/(−4)-29]

5/4 [6/(−4)-18]

0.243

TLC%

117/110 (31/88–184)

104/100 (1/92–101)

0.3830

117/114 (18/90–147)

106/105 (15/86–140)

0.096

TLC litres

4/4 (1/3–6)

19/5 (36/3–101)

0.3308

4/4 (1/2–6)

5/5 (2/2–7)

0.009

RV/TLC %

167/166 (53/112–254)

131/135 (42/77–199)

0.0579

175/181 (28/125–222)

132/127 (25/98–184)

< 0.0001

Abnormal RV/TLC %

4(57)

3(43)

0.5930

8(89)

3(33)

0.016

ACT score^a

14/14 (6/8–21)

19/20 (6/12–24)

0.2486

15/15 (5/8–25)

19/19 (5/13–25)

0.022

Percentage of ACT score ≤ 19 ^a

4(67)

3(50)

0.6963

7(78)

5(56)

0.317

n = 5

n = 5

n = 2

n = 2

LCI

11.1/10.9 (2/8.6–13.6)

9.6/8.3 (2.4/7.2–12.8)

0.3435

12.4/12.4 (2.7/10.5–14.3)

8.5/8.5 (0.3/8.3–8.7)

–

Abnormal LCI (%)

5(100)

4(80)

0.2918

–

–

–

FRC/body weight (mL/kg)

50/47 (11/38–62)

56/48 (18/34–79)

0.2347

49/49 (10/41–58)

60/60 (10/50–70)

–

FeNO (ppb)^a

32/25 (29/8–87)

42/49 (29/6–76)

0.4576

27/16 (24/6–60)

31/14 (37/4–100)

0.728

Abnormal FeNO^a

3(50)

4(67)

0.5582

2(33)

2(33)

–