Table 1 Characteristics of the included randomised controlled trials
Author, year | Setting | Study population | Proportion of females (%) | Mean/median age (months) | Follow-up duration (days) | Dose of paracetamol/ibuprofen | Number of participants paracetamol/ ibuprofen | Cases of asthma paracetamol/ ibuprofen |
|---|---|---|---|---|---|---|---|---|
Lesko et al. 1995 [19] | Outpatient paediatric and family medicine practice throughout the US (1991–1993) | Children aged 6 months to 12 years with acute febrile illness (Boston University Fever Study) | 48 | 40 | 28 | 12 mg/kg / 5-10 mg/kg | 28,130 / 55,739 | 24 / 44 |
Luo et al. 2017 [22] | Tertiary hospital in China (2013–2014) | Febrile children aged 6 months to 5 years attending the emergency room | 40 | 30 | 5 | 10 mg/kg / 10 mg/kg | 158 / 157 | 0 / 2 |
McIntyre and Hull 1996 [23] | Tertiary hospital in the UK | Febrile children aged 2 months to 12 years | 41 | 21 | 3 | 50 mg/kg / 20 mg/kg | 74 / 76 | 2 / 0 |
Sheehan et al. 2016 [24] | 18 hospitals in the US (2013–2015) | Children aged 1 to 6 years receiving long-term step 2 asthma-controller therapy (The Acetaminophen versus Ibuprofen in Children with Asthma trial) | 40 | 40 | 336 | 15 mg/kg / 9.4 mg/kg | 150 / 150 | 74 / 70a |
Wong et al. 2001 [25] | University hospitals in Argentina, Mexico, Chile, and Brazil (1998) | Febrile children aged 6 months to 6 years | 46 | 30 | 0.25 | 12 mg/kg / 5-10 mg/kg | 210 / 209 | 0 / 2 |