Risk of wheezing and asthma exacerbation in children treated with paracetamol versus ibuprofen: a systematic review and meta-analysis of randomised controlled trials

Table 2 Assessment of risk of bias of the included randomised controlled trials

Author, year	Random sequence generation	Allocation concealment	Blinding of participants and personnel	Blinding of outcome assessment	Incomplete outcome data	Selective reporting	Exposure assessment^a	Outcome assessment^a
Lesko et al. 1995 [19]	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk	High risk	High risk
Luo et al. 2017 [22]	Low risk	Low risk	High risk	High risk	Low risk	Low risk	Low risk	Low risk
McIntyre and Hull 1996 [23]	Low risk	High risk	High risk	High risk	Low risk	Low risk	Low risk	Low risk
Sheehan et al. 2016 [24]	Low risk	Low risk	Low risk	Low risk	High risk	Low risk	Unclear	Low risk
Wong et al. 2001 [25]	Low risk	High risk	Low risk	High risk	Low risk	Low risk	Low risk	Low risk

^a Exposure and outcome assessment were considered low risk if the information was obtained from medical records or directly recorded by the investigators, and high risk if it was self-reported by the parents or guardians of the children
The other items of the risk of bias were classified as low or high risk following the Cochrane collaboration’s tool for assessing the bias in randomized trials [16]

ISSN: 1471-2466