Circulating matrix metalloproteinases and tissue metalloproteinase inhibitors in patients with idiopathic pulmonary fibrosis in the multicenter IPF-PRO Registry cohort

Table 3 Association between MMPs/TIMPs and clinical measures of IPF severity

Protein	Association with FVC % predicted			Association with DL_CO % predicted			Association with CPI
Protein	Estimated effect (β)^a	Estimated effect^b	Corrected p-value^c	Estimated effect (β)^a	Estimated effect^b	Corrected p-value^c	Estimated effect (β)^a	Estimated effect^b	Corrected p-value^c
MMP1	−0.72	−0.0747	0.7547	−1.82	−0.1717	0.2488	1.28	0.1325	0.3279
MMP2	4.93	0.0391	0.2859	−1.27	−0.0284	0.7314	0.03	0.0006	0.9886
MMP3	2.35	0.0729	0.7547	−3.94	−0.1193	0.2700	2.26	0.0430	0.4260
MMP7	−10.22	−0.4649	0.1616	*−13.41*	*−1.0998*	*0.0074*	*11.01*	*0.8748*	*0.0056*
MMP8	−6.34	−0.2639	0.1616	*−5.90*	*−0.6893*	*0.0409*	*5.47*	*0.5862*	*0.0151*
MMP9	−7.96	−1.2797	0.1518	−3.87	−0.6113	0.2488	*5.34*	*1.0360*	*0.0286*
MMP12	−3.90	−0.4665	0.1871	*−5.54*	*−0.5672*	*0.0074*	*4.37*	*0.4930*	*0.0073*
MMP13	−2.98	−0.2180	0.2503	*−6.37*	*−0.8935*	*0.0005*	*4.70*	*0.6179*	*0.0016*
TIMP1	−1.06	−0.0007	0.8715	0.57	0.0195	0.9173	1.15	0.0242	0.8708
TIMP2	−3.36	−0.0026	0.7547	−6.75	−0.0237	0.4094	5.49	0.0379	0.4260
TIMP4	−2.66	−0.0059	0.7547	*−11.80*	*−0.9541*	*0.0261*	*7.94*	*0.6367*	*0.0497*

^aEstimated difference in disease severity measure per 10-fold increase in protein concentration, as determined by the linear regression model
^bThe estimated linear regression coefficients (B) and confidence intervals were used to calculate the estimated difference in the disease severity measure going from the median of tertile 1 to the median of tertile 3 in MMP or TIMP concentration
^cp-value determined by linear regression corrected for multiplicity using the Benjamini-Hochberg method to control the false discovery rate at 5%

ISSN: 1471-2466