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Table 1 Basic characteristics of the studies included in the meta-analysis

From: The characteristics of the frequent exacerbator with chronic bronchitis phenotype and non-exacerbator phenotype in patients with chronic obstructive pulmonary disease: a meta-analysis and system review

Author

Year

Country

Language

Research type

Cases

(FE-CB/NE)

Gender (male)

(FE-CB/NE)

Age (years) (FE-CB/NE)

Evaluation indices

Alcázar-Navarrete, B.

2016

Spain

English

Cross-sectional observation study

34/34

32/29

72 ± 10.471 ± 9.9

FEV1%, FEV1/FVC, FVC%, BMI, the quantity of cigarettes smoked (pack-years), CAT score

Arkhipov, V.

2017

Russia

English

Cross-sectional observation study

415/398

356/347

64.6 ± 8.564.7 ± 8.9

FEV1%, the quantity of cigarettes smoked (pack-years), BMI, CAT score

Calle Rubio, M.

2017

Spain

English

Cross-sectional observation study

188/307

157/255

69.5 ± 8.667.2 ± 9.3

FEV1, FEV1%, the quantity of cigarettes smoked (pack-years), CAT, mMRC, BODEx, exacerbations in previous year, BMI

Chee-Shee Chai

2019

Malaysia

English

Cross-sectional observation study

75/54

70/50

70.7 ± 9.274.1 ± 8.1

FEV1%, the quantity of cigarettes smoked (pack-years), CAT, mMRC, exacerbations in previous year

Corlateanu, A.

2017

Moldova

English

Cross-sectional observation study

138/175

 

FVC%, FEV1%, FEV1/FVC, CAT

Cosio, B. G.

2016

Spain

English

Cross-sectional observation study

99/550

85/460

69.5 ± 8.167.4 ± 9.1

FEV1%, FVC%, FEV1/FVC, the quantity of cigarettes smoked (pack-years), BMI, CAT, Charlson comorbidity index

Golpe, R.

2018

Spain

English

Cross-sectional observation study

194/531

167/433

72.7 ± 8.968.5 ± 9.5

FEV1%, FVC%, FEV1/FVC, BMI, BODEx, Charlson comorbidity index

Koblizek, V.

2017

Czech

English

Cross-sectional observation study

687/2125

494/1500

66.6 ± 8.366.3 ± 8.7

FEV1%, FVC%, BMI, CAT, mMRC, exacerbations in previous year

Miravitlles, M.

2015

Germany

English

Cross-sectional observation study

602/1894

514/1617

69.3 ± 9.266.6 ± 9.7

FEV1%, FVC%, FEV1, FVC, FEV1/FVC, mMRC, exacerbations in previous year, BODEx, CAT, BMI, the quantity of cigarettes smoked (pack-years), Charlson comorbidity index

Pan Qing

2016

China

Chinese

Cross-sectional observation study

267/82

217/68

76 ± 10.061 ± 6.4

FEV1、FEV1%

  1. FE-CB: frequent exacerbators with chronic bronchitis; NE: non-exacerbator; FVC: forced vital capacity; FEV1: forced expiratory volume in one second; CAT: COPD assessment test; BMI: body mass index; mMRC: modified British Medical Research Council dyspnea scale;BODEx: BMI, obstruction, dyspnea, exacerbations; FVC%pred: forced vital capacity percent predicted; FEV1%pred: forced expiratory volume in one second percent predicted