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Table 2 Participant characteristics and study baseline measurements

From: The effect of 50% oxygen on PtCO2 in patients with stable COPD, bronchiectasis, and neuromuscular disease or kyphoscoliosis: randomised cross-over trials

 

Neuromuscular disease/

Kyphoscoliosis

N = 20a

Bronchiectasis

N = 24a

COPD

N = 24a

N (%)

Diagnosis

Neuromuscular disease: 18

Kyphoscoliosis: 2b

Bronchiectasis: 24

Cystic Fibrosis: 0

COPD: 24

Male

8 (40%)

7 (29%)

12 (50%)

Home NIV

4 (20%)

2 (8%)

1 (4%)

Home oxygen

1 (5%)

0 (0%)

0 (0%)

Smoking status

Total N = 18c

Total N = 23c

Total N = 18c

- Current

1 (6%)

0 (0%)

3 (17%)

- Ex

7 (39%)

3 (13%)

15 (83%)

- Never

10 (56%)

20 (87%)

0 (0%)

Mean (SD)

Age (years)

52.2 (14.9)

63.0 (12.0)

69.4 (7.3)

BMI (kg/m2)

25.3 (7.2)

27.1 (4.7)

27.9 (4.8)

Smoking pack years

4.2 (9.1)

0.6 (2.2)

35.5 (22.9)

FEV1 percentage predicted (%)

57.6 (20.5)

69.9 (22.4)

65.7 (17.3)

FVC percentage predicted (%)

57.7 (20.5)

87.4 (21.5)

97.5 (17.9)

FEV1/FVC ratio (%)

83.0 (7.3)

64.6 (12.2)

53.5 (11.1)

PtCO2 (mmHg)

38.7 (4.8)

36.6 (3.4)

35.7 (3.5)d

- Min to max

27.8 to 48.6

29.3 to 42.8

29.8 to 42.1

Oxygen saturation (%)

95.7 (2.4)

96.3 (1.3)

95.4 (2.5)d

- Min to max

91 to 100

93 to 99

87 to 99

Respiratory rate (breaths/minute)

18.8 (4.5)

16.8 (3.2)

17.0 (3.9)

Neuromuscular disease/kyphoscoliosis study entry criteria and diagnoses, N

Participants with SNIP < 95% rangee

12

NA

NA

Participants with VC drop ≥10% sitting to lyingf

13

NA

NA

Neuromuscular Diagnosis

 

NA

NA

- Charcot Marie Tooth

3

  

- Facioscapulohumeral muscular dystrophy

2

  

- Limb girdle muscular dystrophy

1

  

- Motor neurone disease

5

  

- Multiple sclerosis

1

  

- Myotonic dystrophy

4

  

- Phrenic nerve palsy

1

  

- Tetraplegia

1

  
  1. COPD Chronic Obstructive Pulmonary Disease, BMI Body mass index, FEV1 Forced expiratory volume in 1 s, FVC Forced vital capacity, NA Not applicable, NIV Non-invasive ventilation, PtCO2 Transcutaneous partial pressure of carbon dioxide, SNIP Sniff nasal inspiratory pressure, VC Vital capacity (slow)
  2. a Unless otherwise stated
  3. b One kyphoscoliosis participant also had Ehlers-Danlos Syndrome, and meet both the spirometry and SNIP entry criteria for neuromuscular disease patients
  4. c Data unavailable from some participants. In the COPD study six participants did not report whether they were current or ex smokers, however all had pack year histories of at least 19 years
  5. dN = 23, data unavailable due to SenTec failure, see Fig. 1 and Online Supplement for details
  6. eTotal N in which data was measured = 19
  7. fTotal N in which data was measured = 18
  8. See Online Supplement for ethnicity and respiratory comorbidity data