Fig. 3
From: The dietary antioxidant quercetin reduces hallmarks of bleomycin-induced lung fibrogenesis in mice
Single pharyngeal bleomycin instillation induces inflammatory lesions with some focal increase of collagenous fibers in Nrf2−/− mice to a lesser extent than in Nrf2+/+ mice. Effects of bleomycin treatment in representative Nrf2+/+ and Nrf2−/− mice are shown for (a-h) Masson Trichome staining of lung tissue showing nuclei (dark brown), cytoplasm (pink) and collagen (blue) and (i) histopathological score of the lung tissue (n = 5–6 mice/group). Data are expressed as typical example (panel A-H) or mean ± SEM (panel I); * P < 0.05; ** P < 0.01