Table 4 Outcomes and the incidence of complications of VV ECMO in the treatment of neonatal respiratory failure
Outcome | Number of studies reporting outcome | summary point estimate (CI 95%) |
|---|---|---|
Hospital mortality | ||
Pooled mortality | 4 (347) | 12% (5–18%) |
Mortality during ECMO | 2 (179) | 10% (0.8–19.2%) |
Mortality after decannulation | 2 (179) | 6.1% (2.6–9.6%) |
Medical complications | ||
Gastrointestinal bleeding | 1 (107) | 3.7% (0.1–7.3%) |
Intracranial hemorrage/infarction | 3 (293) | 6.6% (3.7–9.4%) |
Cannula site bleeding | 2 (179) | 4.4% (−1.8–10.6%) |
Hemolysis | 1 (114) | 5.3% (1.2–9.4%) |
Other bleeding events | 1 (107) | 2.8% (−0.3–5.9%) |
Seizure | 2 (161) | 14.9% (9.4–20.4%) |
Brain death | 1 (107) | 1.9% (−0.7–4.4%) |
Pneumothorax | 1 (107) | 20.6% (12.9–28.2%) |
Hypertension | 1 (54) | 20.4% (9.6–31.1%) |
Myocardiac stun | 1 (114) | 0.9% (−0.8–2.6%) |
Renal failure needing hemofiltration | 3 (275) | 14.7% (5.9–23.5%) |
Infectious complications | 1 (107) | 10.3% (4.5–16%) |
Thrombi | 1 (54) | 7.4% (0.4–14.4%) |
Mechanical complications | ||
Oxygenator failure | 1 (72) | 2.8% (−1.0–6.6%) |
Cannula failure | 2 (126) | 20.2% (−4.2–44.7%) |