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Table 4 Cross-sectional and longitudinal estimates for the association between FEV1 and disease-specific HRQL as measured with the SGRQ

From: Health-related quality of life associates with change in FEV1 in COPD: results from the COSYCONET cohort

Outcome: SGRQ

Total sample

GOLD 1/2

GOLD 3/4

 

estimate [95% CI]

estimate [95% CI]

estimate [95% CI]

FEV1 between-subjects

−1.42*

[− 1.55 to − 1.29]

−1.00*

[− 1.23 to −0.78]

−1.57*

[− 1.95 to − 1.19]

FEV1 within-subjects

0.83*

[0.65 to 1.01]

0.86*

[0.63 to 1.09]

0.92*

[0.60 to 1.23]

  1. *p < 0.001
  2. Hierarchical linear models (HLM) adjusted for age, sex, BMI, education, smoking status, number of comorbidities, and exacerbation history
  3. Interpretation: Positive estimates indicate deterioration in HRQL. FEV1 between-subjects: cross-sectional difference in HRQL per 100 ml difference in FEV1 between subjects. FEV1 within-subjects: longitudinal change in HRQL per 100 ml decrease in FEV1 within subjects over time