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Table 1 Comparison of baseline characteristics of lung cancer patients with or without pneumonia

From: Smoking is associated with pneumonia development in lung cancer patients

Characteristic

Pneumonia (n = 118)

Non-pneumonia (n = 295)

p-value

Age, year

69.79 ± 8.35

66.37 ± 10.60

0.002

Sex, male

98 (83.1)

205 (69.5)

0.005

BMI, kg/m2

22.80 ± 2.943

23.52 ± 3.121

0.887

Smoking history

  

0.002

 Never

17 (14.4)

91 (30.8)

0.001

 Former

53 (44.9)

113 (38.3)

0.216

 Current

48 (40.7)

91 (30.8)

0.056

 Pack-years

39.85 ± 23.83

39.89 ± 25.50

0.992

 Underlying disease

97 (82.2)

235 (78.9)

0.444

 Accompanied cancer

15 (12.7)

47 (75.8)

0.430

Pathology

  

0.004

 Adenocarcinoma

53 (44.9)

183 (62.0)

0.002

 SqCC

32 (27.1)

64 (21.7)

0.238

 SCLC

29 (24.6)

29 (9.8)

< 0.001

 Adenosquamous

1 (0.8)

5 (1.7)

0.516

 Large cell

1 (0.8)

2 (0.7)

0.885

 NOS

0 (0)

1 (0.3)

0.527

 Mesothelioma

0 (0)

0 (0)

 

 Others

2 (1.7)

8 (2.7)

0.354

Line of therapy

  

0.067

 0

7 (5.9)

24 (8.2)

 

 1

57 (48.3)

139 (47.3)

 

 2

25 (21.2)

87 (29.6)

 

  ≥ 3

29 (24.6)

44 (15.0)

 

Neutropenia

51 (43.2)

56 (18.9)

< 0.001

PFT

 FVC, % pred

82.25 ± 16.810

87.77 ± 19.349

0.218

 FEV1, % pred

78.39 ± 19.219

83.93 ± 22.878

0.083

 FEV1/FVC < 70%

47 (49.5)

93 (40.8)

0.151

 FEV1/FVC

0.90 ± 0.297

0.93 ± 0.259

0.103

Clinical stage

  

< 0.001

 I

15 (12.7)

100 (33.9)

< 0.001

 II

10 (8.5)

19 (4.6)

0.476

 III

47 (39.8)

50 (16.9)

< 0.001

 IV

46 (39.0)

124 (42.0)

0.534

Treatment modality

  

< 0.001

 No therapy

7 (5.9)

22 (7.5)

0.567

 Surgery

26 (22.0)

107 (36.6)

0.004

 Chemotherapy

47 (39.8)

75 (25.7)

0.005

 TKI

7 (5.9)

47 (16.1)

0.006

 CCRT

17 (14.4)

18 (6.2)

0.007

 SBRT

0 (0)

2 (0.7)

0.367

 RT

11 (9.3)

14 (4.8)

0.083

 Neo-adjuvant CCRT

0 (0)

3 (1.0)

0.247

  1. Data are expressed as mean ± standard deviation or number (%) except where otherwise indicated
  2. Abbreviations: BMI, body mass index; SqCC, squamous cell carcinoma; SCLC, small cell lung cancer; NOS, not otherwise specified; PFT, pulmonary function test; FVC, forced vital capacity; pred, predictive value; FEV1, forced expiratory volume in 1 s; TKI, tyrosine kinase inhibitor; CCRT, concurrent chemoradiation therapy; SBRT, stereotactic body radiation therapy; RT, radiation therapy