Table 2 Tolerability and adverse drug reactions (ADRs) of pirfenidone therapy
Full dose treatment, n (%) | 272 (88.6) |
Different than full dose treatment, n (%) | 35 (11.4) |
Intermittent drug interruption and/or reduction of dosing, n (%) | 74 (24.1) |
ADRs | |
Nausea, n (%) | 75 (24.43) |
Decreased appetite, n (%) | 105 (34.2) |
Diarrhoea, n (%) | 33 (10.75) |
Vomiting, n (%) | 15 (4.89) |
Dyspepsia, n (%) | 71 (23.13) |
Loss of weight, n (%) | 100 (32.57) |
Cough, n (%) | 88 (28.66) |
Fatigue, n (%) | 110 (35.83) |
Dizziness, n (%) | 42 (13.68) |
Skin rash, n (%) | 58 (18.89) |
Photosensitivity, n (%) | 54 (17.59) |
Elevated liver enzymes, n (%) | 9 (2.93) |
Sleep disturbances, n (%) | 49 (15.96) |
Other, n (%) | 36 (11.73) |