Table 1 Baseline characteristics of 114 patients with NTM pulmonary disease according to their clinical course
Patients who were observed without treatment (n = 61) | Patients who needed treatment with antibiotics (n = 53) | ||
|---|---|---|---|
Microbiologic cure (n = 24) | Treatment failure (n = 29) | ||
Age, years | 64 (54–72) | 61 (54–70) | 63 (57–70) |
Female sex | 40 (65.6) | 19 (79.2) | 24 (82.8) |
BMI, kg/m2* | 21.4 (19.8–22.9) | 21.1 (19.9–22.1) | 19.4 (17.8–21.4) |
Current/former smoker, n (%) | 14 (23.0) | 6 (25.0) | 4 (13.8) |
Comorbidities, n (%) | |||
History of tuberculosis | 23 (37.7) | 10 (41.7) | 9 (31.0) |
Diabetes mellitus | 4 (6.6) | 2 (8.3) | 2 (6.9) |
Malignancy | 6 (9.8) | 3 (12.5) | 3 (10.3) |
COPD | 8 (13.1) | 3 (12.5) | 2 (6.9) |
Radiographic features, n (%) | |||
Non-cavitary nodular bronchiectatic | 51 (83.7) | 16 (66.7) | 18 (62.1) |
Cavitary nodular bronchiectatic | 7 (11.5) | 3 (12.5) | 6 (20.7) |
Fibrocavitary | 3 (4.8) | 5 (20.8) | 5 (17.2) |
Acid-fast bacilli smear positivity, n (%) | 9 (10.7) | 7 (5.1) | 4 (4.2) |
NTM species, n (%) | |||
Mycobacterium avium complex | |||
avium | 28 (46.0) | 13 (54.2) | 9 (31.0) |
intracellulare | 12 (19.7) | 8 (33.3) | 12 (41.4) |
Other avium complexa | 1 (1.6) | 1 (3.4) | 1 (4.2) |
Mycobacterium abscessus complex | |||
Subsp. abscessus | 13 (21.3) | 0 | 2 (6.9) |
Subsp. massiliense | 5 (8.2) | 2 (8.3) | 5 (17.2) |
Subsp. bolletii | 1 (1.6) | 0 | 0 |
Mycobacterium kansasii | 1 (1.6) | 0 | 0 |