Development of chronic lung impairment in Mozambican TB patients and associated risks

Khosa, Celso; Bhatt, Nilesh; Massango, Isabel; Azam, Khalide; Saathoff, Elmar; Bakuli, Abhishek; Riess, Friedrich; Ivanova, Olena; Hoelscher, Michael; Rachow, Andrea

doi:10.1186/s12890-020-1167-1

BMC Pulmonary Medicine

Table 3 Risk factors for LI at week 52

From: Development of chronic lung impairment in Mozambican TB patients and associated risks

Baseline^a	Comparator^a	Severity grade of LI	Relative Risk Ratio (RRR)	95% CI for RRR	p-value
Male	Female	mild	5.07	1.10, 23.45	0.04
Male	Female	moderate/severe	4.38	0.99, 19.36	0.05
Age < 40 years	Age ≥ 40 years	mild	0.53	0.11, 2.52	0.43
Age < 40 years	Age ≥ 40 years	moderate/severe	1.24	0.34, 4.56	0.74
BMI ≥18.5	BMI < 18.5	mild	2.19	0.61, 7.81	0.23
BMI ≥18.5	BMI < 18.5	moderate/severe	1.00	0.29, 3.42	0.99
HIV-negative	HIV-positive	mild	1.79	0.47, 6.85	0.39
HIV-negative	HIV-positive	moderate/severe	1.00	0.30, 3.33	0.99
CD4 < 200/μl	CD4 ≥ 200/μl	mild	3.60	0.71, 18.25	0.12
CD4 < 200/μl	CD4 ≥ 200/μl	moderate/severe	1.87	0.39, 8.89	0.43
Culture conversion until week 8	No culture conversion until week 8	mild	1.71	0.47, 6.24	0.41
Culture conversion until week 8	No culture conversion until week 8	moderate/severe	2.57	0.75, 8.78	0.13
Culture conversion until week 26	No culture conversion until week 26	mild	2.63	0.22, 31.57	0.45
Culture conversion until week 26	No culture conversion until week 26	moderate/severe	1.00	0.06, 17.07	0.99
Never smoked (males only)	Ever smoked (males only)	mild	0.15	0.02, 0.89	0.04
Never smoked (males only)	Ever smoked (males only)	moderate/severe	0.71	0.19, 3.58	0.93
< 10 Pack Years^b	≥10 Pack Years^b	mild	–	–	–
< 10 Pack Years^b	≥10 Pack Years^b	moderate/severe	7.50	0.92, 61.05	0.06
No critical alcohol consumption^b	Critical alcohol consumption^b	mild	0.69	0.14, 3.40	0.65
No critical alcohol consumption^b	Critical alcohol consumption^b	moderate/severe	1.50	0.34, 6.59	0.59
C-reactive protein < 100 mg/dL	C-reactive protein ≥100 mg/dL	mild	0.77	0.19, 3.11	0.72
C-reactive protein < 100 mg/dL	C-reactive protein ≥100 mg/dL	moderate/severe	0.58	0.15, 2.26	0.43
Haemoglobin, per 1 g/dl increase at baseline		mild	0.67	0.47, 0.95	0.02
Haemoglobin, per 1 g/dl increase at baseline		moderate/severe	0.69	0.49, 0.96	0.03
Overall affected lung, each 1% increase		mild	0.97	0.90, 1.05	0.43
Overall affected lung, each 1% increase		moderate/severe	1.01	0.95, 1.08	0.68

Risk factor analysis using univariable multinomial regression model, comparing subjects with no impairment at week 52 (n = 24) with those who have mild impairment (n = 22) or moderate/severe impairment (n = 16) at week 52. The absolute numbers and proportions of subjects in each individual stratum (baseline, comparator, mild LI and moderate/severe LI) can be found in S2 table
^amissing observations: CRP for 4 participants, Pack Years (PY) for 2 participants, amount of alcohol consumption for 2 participants
^bdefinitions:
- Pack Years (PY): lifetime exposure to cigarette smoking, e.g. ≥10PY means that the respective study participant smoked an equivalent of one pack of cigarettes every day for at least 10 years (e.g. 1 pack of cigarettes on every day for 10 years, or 2 packs of cigarettes on every day for 5 years, or ½ packs of cigarettes on every day for 20 years) at baseline study visit. PY were only calculated for those 20 male study participants who reported to have “ever smoked” during their lifetime and provided information on PY
- Critical alcohol consumption: in men (women) more than 60 g (30 g) alcohol per occasion of alcohol drinking and/or more than 150 g (80 g) alcohol per week, according to the International Alliance for Responsible Drinking for general population [31]

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ISSN: 1471-2466

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