Fig. 2

MRI of brain during different periods of treatment a Contrast-enhanced MRI of brain showed heterogeneously enhancing lesions at the posterior horn of the right lateral ventricle and the IV ventricle, with upper ventricle hydrocephalus and edema of the surrounding parenchyma. T2FLAIR showed slightly higher signal of the masses. b Intraventricular lesions and surrounding area of edema observably shrunk with restored ventricular dilatation after 3-month treatment with afitinib. c Masses in the brain remain stable after 10-month treatment while lesions of lung progressed