Fig. 4

Observed and predicted evolution of markers of lung function and growth. Lung function (FEV1% predicted, upper left y-axis) and growth (BMIp, lower left y-axis) and probability of not having a pulmonary exacerbation (PE-free probability, upper/lower right y-axis) in a female CF F508del homozygous patient over a series of four clinical encounters (observations are black dots; mean response is black curve). Arrows illustrate how her probability of remaining PE-free is dynamically updated with each clinical encounter