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Table 1 Cohort characteristics according to PE onset*

From: Multivariate joint modeling to identify markers of growth and lung function decline that predict cystic fibrosis pulmonary exacerbation onset

Characteristic at Baseline

Had PE during follow up (n = 5510)

PE-free during follow up (n = 10,945)

Overall (n = 16,455)

Genotype^

 Homozygous

53.0%

45.6%

48.1%

 Heterozygous

36.4%

39.1%

38.2%

 None/unknown

10.6%

15.3%

13.7%

Male sex^

47.4%

53.7%

51.6%

Hispanic

9.2%

8.5%

8.7%

Birth cohort^

  < 1981

16.7%

19.8%

18.8%

 1981–1989

31.6%

22.2%

25.3%

 1990–1994

22.0%

13.9%

16.6%

 1995–1999

24.6%

26.9%

26.1%

  > 1999

5.1%

17.2%

13.2%

Age at entry, years^

8.7 (6.2–13.0)

7.9 (6.2–14.0)

8.2 (6.2–13.6)

Low SES

54.0%

52.4%

49.8%

MRSA^

9.5%

6.4%

7.4%

Pa^

24.2%

17.3%

19.6%

CFRD^

5.1%

3.2%

3.9%

Pancreatic insufficient^

32.3%

42.3%

39.0%

FEV1, % predicted^

83.8 (67.3–98.0)

93.5 (79.3–105.2)

90.6 (74.9–103.2)

BMIp, percentile^

43.1 (19.9–67.0)

51.1 (27.3–73.4)

48.6 (24.8–71.3)

WFA, percentile^

29.1 (10.2–55.0)

38.9 (16.7–64.7)

35.5 (14.3–61.7)

HFA, percentile^

24.5 (8.4–49.8)

32.4 (12.3–59.5)

29.7 (10.7–56.7)

Length of follow up, years^

1.9 (0.5–4.4)

3.1 (1.0–6.3)

2.6 (0.8–5.7)

Alive^

99.9%

99.7%

99.8%

  1. Abbreviations: BMIp body mass index percentile, CFRD cystic fibrosis related diabetes, FEV1 forced expiratory volume in 1 s, HFA height for age, MRSA methicillin-resistant Staphylococcus aureus, Pa Pseudomonas aeruginosa, PE pulmonary exacerbation, SES socioeconomic status, WFA weight for age. * Values at first recorded entry in the database are used for all patients except for follow-up and death; results for continuous and categorical variables are expressed as median (Q1-Q3) and % over column total, respectively. Characteristics marked as ^ imply P < 0.05 for comparison between PE and PE-free groups. Between-group frequencies compared using Chi-square test of independence; continuous variables compared between groups using Welch two-sample t-test