Table 1 Laboratory investigations, ventilator settings and sedative drugs
From: Salbutamol-induced lactic acidosis in status asthmaticus survivor
0 h | 6 h | 12 h | 24 h | 32 h | 48 h | 54 h | |
|---|---|---|---|---|---|---|---|
Arterial blood gas | |||||||
PH | 6.98 | 7.29 | 7.24 | 7.26 | 7.42 | 7.43 | 7.45 |
PaO2 (mm Hg) | 90 | 91.9 | 119.2 | 95.6 | 61.9 | 79.2 | 76 |
PaCO2 (mm Hg) | 119.5 | 55.6 | 48 | 52 | 44 | 42.8 | 38.4 |
HCO3 (mmol/L) | 20 | 22 | 16 | 12 | 22 | 25 | 25 |
Serum lactate (mmol/L) | 4.4 | 0.7 | 2.3 | 4.6 | 1.3 | 0.9 | 0.7 |
Creatinine phosphokinase (U/L) | – | – | 1,877 | 2,007 | – | 1,454 | 880 |
Creatinine (mg/dL) | 0.87 | – | 1.16 | – | – | 1.06 | 0.92 |
Potassium (mmol/L) | 3.8 | 5.3 | 5.4 | 4.4 | 4 | 3.9 | 4.2 |
Ventilator settings | |||||||
Mode | VCV | VCV | VCV | VCV | VCV | PSV | PSV |
Tidal volume (ml/kg) | 5.5 | 5.5 | 4.3 | 4.3 | 6 | 6–7 | 6–7 |
Tidal volume (ml) | 380–390 | 380–390 | 300 | 300 | 420 | 420–490 | 420–490 |
PEEP (cm H2O) | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
Respiratory rate (/min) | 20–25 | 20–25 | 14 | 14 | 14 | 14 | 14 |
Flow (L/min) | 60 | 60 | 70–100 | 70–100 | 60 | – | – |
FiO2 | 0.6 | 0.4 | 0.4 | 0.4 | 0.3 | 0.3 | 0.3 |
Drugs | |||||||
Propofol (mg/h) | – | 200 | 100 | 100 | 60 | off | – |
Fentanyl (mcg/h) | 50 | 80 | 50 | 80 | 80 | 80 | 50 |
Midazolam (mg/h) | 4 | 5 | 6 | 6 | 4 | off | – |
Cisatracurium (mcg/kg/min) | – | 2.2 | 2.2 | off | – | – | – |
Salbutamol inhaler (puffs) | N/A | N/A | N/A | Total 315 → off | – | – | – |