Table 1 Baseline characteristics of patients with COPD in the cohort
Characteristics | Total (n = 62) | Low IL-33 (n = 45) | High IL-33 (n = 17) | P value |
|---|---|---|---|---|
Age (years) | 65.1 ± 9.0 | 66.9 ± 8.8 | 60.1 ± 7.8 | 0.01 |
Male | 61 (98.4%) | 44 (97.8%) | 17 (100.0%) | 1.00 |
Smoking status | ||||
Current smoker | 30 (48.4%) | 25 (55.6%) | 5 (29.4%) | 0.09 |
Ex-smoker | 32 (51.6%) | 20 (44.4%) | 12 (70.6%) | |
Pack years | 44.1 ± 21.5 | 45.8 ± 19.8 | 39.7 ± 25.7 | 0.17 |
BMI (kg/m2) | 23.2 ± 3.4 | 23.3 ± 3.3 | 22.9 ± 3.8 | 0.88 |
PFT | ||||
Post BD FVC (L) | 3.51 ± 0.73 | 3.45 ± 0.74 | 3.68 ± 0.68 | 0.42 |
Post BD FVC (%) | 82.1 ± 15.7 | 81.8 ± 17.5 | 82.9 ± 9.9 | 0.94 |
Post BD FEV1 (L) | 1.86 ± 0.68 | 1.84 ± 0.65 | 1.92 ± 0.78 | 0.62 |
Post BD FEV1 (%) | 59.2 ± 17.8 | 60.2 ± 17.2 | 56.6 ± 19.5 | 0.55 |
Post BD FEV1/FVC (%) | 51.9 ± 13.3 | 52.4 ± 12.8 | 50.6 ± 15.0 | 0.80 |
Symptom | ||||
CAT | 14.7 ± 7.2 | 15.2 ± 7.5 | 13.2 ± 6.2 | 0.37 |
mMRC | 0.8 ± 0.9 | 0.8 ± 0.9 | 0.8 ± 0.9 | 0.89 |
Blood eosinophil count (/μl) | 257.4 ± 242.6 | 230.9 ± 228.0 | 327.3 ± 272.4 | 0.16 |
Number of exacerbations/yr | 0.56 ± 0.95 | 0.40 ± 0.62 | 1.00 ± 1.46 | 0.01 |
IL-33 (450 OD) | 0.069 [0.065–0.075] | 0.067 [0.064–0.070] | 0.079 [0.076–0.100] | < 0.01 |
COPD medication | ||||
LABA | 2 (3.2%) | 2 (4.4%) | 0 (0.0%) | 1.00 |
LAMA | 5 (8.1%) | 5 (11.1%) | 0 (0.0%) | 0.31 |
LABALAMA | 12 (19.4%) | 11 (24.4%) | 1 (5.9%) | 0.15 |
ICSLABA | 6 (9.7%) | 3 (6.7%) | 3 (17.6%) | 0.33 |
ICSLABALAMA | 38 (61.3%) | 25 (55.6%) | 13 (76.5%) | 0.16 |