|
Characteristics
|
Never smoker
|
Smoker
|
GOLD 1
|
GOLD 2
|
P value
|
|---|
|
(n = 11)
|
(n = 9)
|
(n = 8)
|
(n = 10)
|
|---|
|
Age (years)
|
65.5 ± 8.6
|
57.9 ± 8.9
|
63.1 ± 7.5
|
66.9 ± 5.6
|
0.08
|
|
Male
|
2 (18.2%)
|
8 (88.9%)
|
8 (100.0%)
|
10 (100.0%)
|
< 0.01
|
|
Smoking status
| | | | | |
|
Current smoker
|
0 (0.0%)
|
2 (22.2%)
|
1 (12.5%)
|
3 (30.0%)
|
< 0.01
|
|
Ex-smoker
|
0 (0.0%)
|
7 (77.8%)
|
7 (87.5%)
|
7 (70.0%)
|
|
Pack years
|
0.0 ± 0.0
|
37.9 ± 35.7
|
31.0 ± 15.1
|
42.1 ± 22.9
|
< 0.01
|
|
PFT
| | | | | |
|
Post BD FVC (L)
|
2.48 ± 0.4
|
3.72 ± 0.9
|
4.30 ± 0.5
|
3.59 ± 0.7
|
< 0.01
|
|
Post BD FVC (%)
|
85.6 ± 10.4
|
84.9 ± 18.2
|
100.4 ± 7.4
|
84.6 ± 10.0
|
0.03
|
|
Post BD FEV1 (L)
|
2.00 ± 0.4
|
3.01 ± 0.6
|
2.76 ± 0.3
|
2.10 ± 0.3
|
< 0.01
|
|
Post BD FEV1 (%)
|
91.8 ± 14.3
|
91.2 ± 14.7
|
87.8 ± 4.7
|
69.2 ± 8.1
|
< 0.01
|
|
Post BD FEV1/FVC (%)
|
80.6 ± 6.9
|
82.0 ± 6.6
|
64.1 ± 4.9
|
59.6 ± 10.0
|
< 0.01
|
|
RV (%)
|
102.9 ± 26.5
|
100.3 ± 30.1
|
113.1 ± 18.0
|
121.4 ± 25.6
|
0.32
|
|
IL-33 stain (%)
|
17.2 ± 9.4
|
18.5 ± 8.4
|
24.4 ± 10.9
|
34.0 ± 12.6
|
< 0.01
|
- Data are expressed as mean ± SD or No. (%)
- GOLD, global initiative for chronic lung disease; PFT, pulmonary function test; BD, bronchodilator; FVC, forced viral capacity; FEV1, forced expiratory volume in 1 s, RV, residual volume; IL, interleukin
