Table 3 IL-33 Baseline characteristics of patients with lung tissue analysis
Characteristics | Never smoker | Smoker | GOLD 1 | GOLD 2 | P value |
|---|---|---|---|---|---|
(n = 11) | (n = 9) | (n = 8) | (n = 10) | ||
Age (years) | 65.5 ± 8.6 | 57.9 ± 8.9 | 63.1 ± 7.5 | 66.9 ± 5.6 | 0.08 |
Male | 2 (18.2%) | 8 (88.9%) | 8 (100.0%) | 10 (100.0%) | < 0.01 |
Smoking status | |||||
Current smoker | 0 (0.0%) | 2 (22.2%) | 1 (12.5%) | 3 (30.0%) | < 0.01 |
Ex-smoker | 0 (0.0%) | 7 (77.8%) | 7 (87.5%) | 7 (70.0%) | |
Pack years | 0.0 ± 0.0 | 37.9 ± 35.7 | 31.0 ± 15.1 | 42.1 ± 22.9 | < 0.01 |
PFT | |||||
Post BD FVC (L) | 2.48 ± 0.4 | 3.72 ± 0.9 | 4.30 ± 0.5 | 3.59 ± 0.7 | < 0.01 |
Post BD FVC (%) | 85.6 ± 10.4 | 84.9 ± 18.2 | 100.4 ± 7.4 | 84.6 ± 10.0 | 0.03 |
Post BD FEV1 (L) | 2.00 ± 0.4 | 3.01 ± 0.6 | 2.76 ± 0.3 | 2.10 ± 0.3 | < 0.01 |
Post BD FEV1 (%) | 91.8 ± 14.3 | 91.2 ± 14.7 | 87.8 ± 4.7 | 69.2 ± 8.1 | < 0.01 |
Post BD FEV1/FVC (%) | 80.6 ± 6.9 | 82.0 ± 6.6 | 64.1 ± 4.9 | 59.6 ± 10.0 | < 0.01 |
RV (%) | 102.9 ± 26.5 | 100.3 ± 30.1 | 113.1 ± 18.0 | 121.4 ± 25.6 | 0.32 |
IL-33 stain (%) | 17.2 ± 9.4 | 18.5 ± 8.4 | 24.4 ± 10.9 | 34.0 ± 12.6 | < 0.01 |