Fig. 8
From: Dynamic evolution of emphysema and airway remodeling in two mouse models of COPD
Airspace enlargement assessed using H&E staining. Six- to eight-week-old male C57BL/6 J mice were exposed to CS for 6 months or CS for 6 months and an intranasal instillation of LPS on days 1 and 14. a CS or CS + LPS exposure induced inflammation in the lung. H&E staining of lung tissues from mice in the control group, CS group and CS + LPS group after 6 months of exposure, original magnification × 200. Bar = 100 μm. The arrows indicate inflammatory cells. b H&E staining of lung tissues from mice sacrificed in the indicated month from the control group (n = 6), CS group (n = 6) and CS + LPS group (n = 6), original magnification × 100. Bar = 100 μm. c Quantification of the MLI of mice sacrificed in the indicated month from the control group (n = 6), CS group (n = 6) and CS + LPS group (n = 6). Data are presented as the means ± SD, N = 6; #P < 0.05; ##P < 0.01 for the comparison of the CS group with the control group; *P < 0.05; **P < 0.01; ***P < 0.001 for the comparison of the CS + LPS group with the control group