Fig. 6

Schematic representation of the mechanism of NF-κB on TNF-α-induced pulmonary inflammatory response via regulating NOX1 in alveolar epithelial type II cells. In TNFα-induced ALI, activated NF-κB can translocate to the nucleus, where it binds to NOX1 promoter regions (κB2, TAAAAATCCC, -261 ~ -252)) and activate the transcription of NOX1 and oxidative stress, which can promote inflammatory and oxidative stress