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Table 4 Baseline airway obstruction in the subcohort of COPD and comparison between sex and residence group

From: Profile and preliminary results of Iranian sub cohort chronic obstructive pulmonary disease (COPD) in Shahrekord PERSIAN cohort in southwest Iran

Variables

All

N = 7978

Men

N = 3824

Women

N = 4154

P value

Urban

N = 6388

Rural

N = 1590

P value

Airway obstruction—LLN

673 (8.4%)

345 (9%)

328 (7.9%)

0.039

558 (8.7%)

115 (7.2%)

0.029

Airways obstruction—FR

289 (3.6%)

159 (4.2%)

130 (3.1%)

0.008

243 (3.8%)

46 (2.9%)

0.045

Chronic lung disease (asthma, tuberculosis, emphysema and bronchitis)—n (%)

346 (4.3%)

155 (4.1%)

191 (4.6%)

0.127

302 (4.7%)

44 (2.8%)

< 0.0001

History of asthma in childhood—n (%)

949 (11.9%)

511 (13.4%)

438 (10.5%)

0.028

756 (11.8%)

193 (12.1%)

0.098

family history of respiratory and pulmonary diseases—n (%)

311 (3.9%)

138 (3.6%)

173 (4.2%)

0.261

251 (3.9%)

60 (3.8%)

0.879

Symptoms

       

 Chronic cough—n (%)

1038 (13%)

383 (10%)

655 (15.8%)

< 0.0001

937 (14.7%)

101 (6.4%)

< 0.0001

 Chronic cough with phlegm—n (%)

494 (47.6%)

201 (52.5%)

293 (44.7%)

0.009

444 (47.4%)

50 (49.5%)

0.382

 Shortness of breath and Wheezing—n (%)

217 (2.7%)

75 (2%)

142 (3.4%)

< 0.0001

188 (2.9%)

29 (1.8%)

0.007

Pre-bronchodilator spirometry (n = 7978)

       

 FEV1 (L.)—mean ± SD

2.84 ± 0.79

2.93 ± 0.81

2.76 ± 0.76

< 0.0001

2.92 ± 0.78

2.55 ± 0.74

< 0.0001

 FEV6 (L.)—mean ± SD

2.08 ± 0.86

3.17 ± 0.87

2.99 ± 0.084

< 0.0001

3.16 ± 0.85

2.74 ± 0.80

< 0.0001

 FVC (L)—mean ± SD

3.08 ± 0.86

3.18 ± 0.88

3.00 ± 0.84

< 0.0001

3.17 ± 0.85

2.74 ± 0.80

< 0.0001

 FEV1/FVC—mean ± SD

92.48 ± 7.47

92.43 ± 7.63

92.52 ± 7.32

0.601

92.27 ± 7.45

93.33 ± 7.50

< 0.0001

 FEV1/FEV6—mean ± SD

92.39 ± 7.48

92.60 ± 7.45

92.62 ± 7.32

0.678

92.42 ± 7.36

93.38 ± 7.41

< 0.0001

 PEF (L)—mean ± SD

5.07 ± 2.09

5.28 ± 2.19

4.88 ± 1.96

< 0.0001

5.24 ± 2.12

4.37 ± 1.79

< 0.0001

 MVV (L/min)—mean ± SD

99.67 ± 27.7

102.54 ± 28.3

97.02 ± 26.96

< 0.0001

102.27 ± 27.55

89.37 ± 26.21

< 0.0001

Post-bronchodilator spirometry (n = 761)

       

 FEV1 (L.)—mean ± SD

3.23 ± 0.21

3.41 ± 0.74

2.98 ± 0.88

< 0.0001

3.35 ± 0.42

2.78 ± 0.81

< 0.0001

 FEV6 (L.)—mean ± SD

2.51 ± 0.74

3.67 ± 0.84

3.12 ± 0.36

< 0.0001

3.41 ± 0.65

2.98 ± 0.63

< 0.0001

 FVC (L)—mean ± SD

3.89 ± 0.48

3.91 ± 0.73

3.84 ± 0.61

< 0.0001

3.99 ± 0.53

2.93 ± 0.61

< 0.0001

 FEV1/FVC—mean ± SD

91.28 ± 6.94

91.40 ± 6.86

91.62 ± 6.82

0.687

91.39 ± 6.87

92.64 ± 6.91

< 0.0001

 FEV1/FEV6—mean ± SD

92.73 ± 7.21

92.92 ± 7.69

92.89 ± 7.41

0.964

92.68 ± 7.44

93.81 ± 7.48

< 0.0001

 PEF (L)—mean ± SD

5.51 ± 2.32

5.68 ± 2.38

5.21 ± 2.01

< 0.0001

5.84 ± 2.39

4.98 ± 1.94

< 0.0001

 MVV (L/min)—mean ± SD

99.87 ± 28.1

102.66 ± 28.2

98.12 ± 28.91

< 0.0001

102.69 ± 27.97

90.21 ± 27.31

< 0.0001

Severity of COPD

       

 Mild

138 (47.8%)

92 (55.1%)

46 (37.7%)

0.003

111 (46.8%)

27 (51.9%)

0.801

 Moderate

116 (40.1%)

52 (31.1%)

64 (52.5%)

 

98 (41.4%)

18 (34.6%)

 Severe

28 (9.8%)

19 (11.4%)

9 (7.4%)

 

22 (9.3%)

6 (11.5%)

 Very severe

7 (2.4%)

4 (2.4%)

3 (2.5%)

 

6 (2.5%)

1 (1.9%)

  1. LLN, low limit normal; FR, fixed ratio; FEV1, forced expiratory volume in 1 second; FEV6, forced expiratory volume in 6 second; FVC, forced vital capacity; PEF, peak expiratory flow