Table 3 Subgroup analysis for the effects of HOMA-IR on annual change in lung function
Exposure: per one unit increase log-transformed HOMA-IR | Adjusted beta (CI, P-value) | Outcome: annual change in lung function | |||
|---|---|---|---|---|---|
∆ FEV1 (%-predicted/year) | ∆ FVC (%-predicted/year) | ||||
P for interaction | Adjusted beta (CI, P-value) | P for interaction | |||
Subgroup | No. of people | ||||
Age (years) | < 50 (n = 2177) | 0.04 (− 0.13 to 0.22, 0.613) | 0.003 | 0.03 (− 0.15 to 0.20, 0.775) | 0.153 |
≥ 50 (n = 2650) | − 0.41 (− 0.58 to − 0.24, < 0.001) | − 0.33 (− 0.51 to − 0.16, < 0.001) | |||
Sex | Male (n = 2186) | − 0.24 (− 0.41 to − 0.07, 0.006) | 0.798 | − 0.15 (− 0.33 to 0.03, 0.103) | 0.554 |
Female (n = 2641) | − 0.22 (− 0.40 to − 0.05, 0.012) | − 0.24 (− 0.41 to − 0.06, 0.008) | |||
Current or past smoker | No (n = 2812) | − 0.18 (− 0.34 to − 0.02, 0.027) | 0.447 | − 0.18 (− 0.34 to − 0.02, 0.012) | 0.941 |
Yes (n = 2015) | − 0.30 (− 0.48 to − 0.11, 0.002) | − 0.18 (− 0.37 to 0.01, 0.060) | |||
Active physical activity | No (n = 2512) | − 0.17 (− 0.32 to − 0.02, 0.028) | 0.496 | − 0.12 (− 0.28 to 0.04, 0.002) | 0.423 |
Yes (n = 2315) | − 0.31 (− 0.50 to − 0.11, 0.002) | − 0.29 (− 0.49 to − 0.10, 0.004) | |||
High BP | No (n = 4043) | − 0.21 (− 0.35 to − 0.08, 0.002) | 0.579 | − 0.20 (− 0.33 to − 0.06, 0.004) | 0.919 |
Yes (n = 784) | − 0.35 (− 0.66 to − 0.03, 0.030) | − 0.27 (− 0.60 to 0.06, 0.104) | |||
Annual averaged BMI (kg/m2) | < 24 (n = 2223) | − 0.30 (− 0.50 to − 0.11, 0.002) | 0.345 | − 0.22 (− 0.42 to − 0.03, 0.023) | 0.998 |
≥ 24 (n = 2604) | − 0.17 (− 0.33 to − 0.02, 0.031) | − 0.19 (− 0.35 to − 0.02, 0.026) | |||
Annual averaged eGFR (mL/min/1.73m2) | < 84 (n = 2496) | − 0.22 (− 0.39 to − 0.05, 0.010) | 0.387 | − 0.10 (− 0.27 to 0.07, 0.256) | 0.751 |
≥ 84 (n = 2331) | − 0.24 (− 0.42 to − 0.06, 0.010) | − 0.31 (− 0.49 to − 0.12, 0.001) | |||
Annual averaged WBC count (× 103/μL) | < 6.3 (n = 2396) | − 0.26 (− 0.44 to − 0.08, 0.006) | 0.643 | − 0.15 (− 0.34 to 0.04, 0.121) | 0.735 |
≥ 6.3 (n = 2431) | − 0.21 (− 0.37 to − 0.05, 0.012) | − 0.22 (− 0.40 to − 0.05, 0.013) | |||
Annual averaged Hemoglobin (mg/dL) | < 13.5 (n = 2462) | − 0.17 (− 0.35 to 0.02, 0.080) | 0.713 | − 0.12 (− 0.31 to 0.07, 0.217) | 0.425 |
≥ 13.5 (n = 2365) | − 0.29 (− 0.45 to − 0.14, < 0.001) | − 0.24 (− 0.40 to − 0.08, 0.004) | |||