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Table 3 Combined effects of selected SNPs and visible mold exposure on childhood asthma under the dominant model

From: Household mold exposure interacts with inflammation-related genetic variants on childhood asthma: a case–control study

SNP/visible mold exposure

No. of asthma cases

Group size

aOR (95% CI)

AP

S

RERI

rs1042713/mold

   

− 0.09 (− 0.70, 0.53)

0.86 (0.32, 2.35)

− 0.19 (− 1.51, 1.13)

AA/no

148

398

Ref

   

GG + GA/no

309

779

1.13 (0.87, 1.47)

   

AA/yes

42

73

2.23 (1.30, 3.86)*

   

GG + GA/yes

109

197

2.17 (1.50, 3.15)*

   

rs1042714/mold

   

0.10 (− 0.51, 0.70)

1.23 (0.32, 4.70)

0.20 (− 1.15, 1.55)

CC/no

376

958

Ref

   

GG + GC/no

81

219

0.91 (0.65, 1.25)

   

CC/yes

120

217

1.96 (1.43, 2.70)*

   

GG + GC/yes

31

53

2.07 (1.15, 3.79)*

   

rs7216389/mold

   

0.47 (0.03, 0.90)

3.08 (0.36, 26.06)

1.49 (0, 2.99)

CC/no

21

69

Ref

   

TT + TC/no

436

1108

1.52 (0.88, 2.70)

   

CC/yes

7

20

1.20 (0.38, 3.65)

   

TT + TC/yes

144

250

3.21 (1.77, 5.99)*

   

rs5498/mold

   

− 0.16 (− 0.74, 0.43)

0.77 (0.31, 1.89)

− 0.34 (− 1.50, 0.83)

AA/no

220

592

Ref

   

GG + GA/no

237

585

1.18 (0.92, 1.51)

   

AA/yes

78

135

2.27 (1.52, 3.42)*

   

GG + GA/yes

73

135

2.11 (1.41, 3.17)*

   

rs1800925/mold

   

0.35 (− 0.03, 0.74)

2.2 (0.75, 6.43)

1.01 (− 0.51, 2.53)

CC/no

318

834

Ref

   

TT + CT/no

139

343

1.05 (0.79, 1.38)

   

CC/yes

102

192

1.79 (1.28, 2.52)*

   

TT + CT/yes

49

78

2.85 (1.72, 4.80)*

   

rs2243250/mold

   

− 0.03 (− 0.61, 0.55)

0.94 (0.25, 3.49)

− 0.05 (− 1.04, 0.94)

TT/no

321

792

Ref

   

CC + CT/no

136

385

0.80 (0.61, 1.04)

   

TT/yes

95

167

1.98 (1.38, 2.85)*

   

CC + CT/yes

56

103

1.73 (1.12, 2.69)*

   

rs1801275/mold

   

− 0.20 (− 0.88, 0.47)

0.67 (0.19, 2.34)

− 0.35 (− 1.40, 0.70)

AA/no

334

849

Ref

   

GG + GA/no

123

328

0.93 (0.70, 1.23)

   

AA/yes

106

181

2.13 (1.51, 3.03)*

   

GG + GA/yes

45

89

1.72 (1.08, 2.73)*

   

rs324015/mold

   

0.39 (− 0.04, 0.81)

5.79 (0.03, 1237.72)

0.73 (− 0.16, 1.61)

CC/no

142

336

Ref

   

TT + CT/no

315

841

0.80 (0.61, 1.05)

   

CC/yes

35

69

1.35 (0.78, 2.35)

   

TT + CT/yes

116

201

1.88 (1.29, 2.74)*

   
  1. SNP single nucleotide polymorphisms, Ref reference, aOR adjusted odds ratio, AP the attributable proportion due to interaction, S the synergy index, RERI the relative excess risk due to interaction
  2. Models were adjusted for age, gender, family history of allergy, parental education level, and ETS before and after birth
  3. *FDR adjusted p value < 0.05; FDR, False discovery rate