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Table 3 Combined effects of selected SNPs and visible mold exposure on childhood asthma under the dominant model

From: Household mold exposure interacts with inflammation-related genetic variants on childhood asthma: a case–control study

SNP/visible mold exposure No. of asthma cases Group size aOR (95% CI) AP S RERI
rs1042713/mold     − 0.09 (− 0.70, 0.53) 0.86 (0.32, 2.35) − 0.19 (− 1.51, 1.13)
AA/no 148 398 Ref    
GG + GA/no 309 779 1.13 (0.87, 1.47)    
AA/yes 42 73 2.23 (1.30, 3.86)*    
GG + GA/yes 109 197 2.17 (1.50, 3.15)*    
rs1042714/mold     0.10 (− 0.51, 0.70) 1.23 (0.32, 4.70) 0.20 (− 1.15, 1.55)
CC/no 376 958 Ref    
GG + GC/no 81 219 0.91 (0.65, 1.25)    
CC/yes 120 217 1.96 (1.43, 2.70)*    
GG + GC/yes 31 53 2.07 (1.15, 3.79)*    
rs7216389/mold     0.47 (0.03, 0.90) 3.08 (0.36, 26.06) 1.49 (0, 2.99)
CC/no 21 69 Ref    
TT + TC/no 436 1108 1.52 (0.88, 2.70)    
CC/yes 7 20 1.20 (0.38, 3.65)    
TT + TC/yes 144 250 3.21 (1.77, 5.99)*    
rs5498/mold     − 0.16 (− 0.74, 0.43) 0.77 (0.31, 1.89) − 0.34 (− 1.50, 0.83)
AA/no 220 592 Ref    
GG + GA/no 237 585 1.18 (0.92, 1.51)    
AA/yes 78 135 2.27 (1.52, 3.42)*    
GG + GA/yes 73 135 2.11 (1.41, 3.17)*    
rs1800925/mold     0.35 (− 0.03, 0.74) 2.2 (0.75, 6.43) 1.01 (− 0.51, 2.53)
CC/no 318 834 Ref    
TT + CT/no 139 343 1.05 (0.79, 1.38)    
CC/yes 102 192 1.79 (1.28, 2.52)*    
TT + CT/yes 49 78 2.85 (1.72, 4.80)*    
rs2243250/mold     − 0.03 (− 0.61, 0.55) 0.94 (0.25, 3.49) − 0.05 (− 1.04, 0.94)
TT/no 321 792 Ref    
CC + CT/no 136 385 0.80 (0.61, 1.04)    
TT/yes 95 167 1.98 (1.38, 2.85)*    
CC + CT/yes 56 103 1.73 (1.12, 2.69)*    
rs1801275/mold     − 0.20 (− 0.88, 0.47) 0.67 (0.19, 2.34) − 0.35 (− 1.40, 0.70)
AA/no 334 849 Ref    
GG + GA/no 123 328 0.93 (0.70, 1.23)    
AA/yes 106 181 2.13 (1.51, 3.03)*    
GG + GA/yes 45 89 1.72 (1.08, 2.73)*    
rs324015/mold     0.39 (− 0.04, 0.81) 5.79 (0.03, 1237.72) 0.73 (− 0.16, 1.61)
CC/no 142 336 Ref    
TT + CT/no 315 841 0.80 (0.61, 1.05)    
CC/yes 35 69 1.35 (0.78, 2.35)    
TT + CT/yes 116 201 1.88 (1.29, 2.74)*    
  1. SNP single nucleotide polymorphisms, Ref reference, aOR adjusted odds ratio, AP the attributable proportion due to interaction, S the synergy index, RERI the relative excess risk due to interaction
  2. Models were adjusted for age, gender, family history of allergy, parental education level, and ETS before and after birth
  3. *FDR adjusted p value < 0.05; FDR, False discovery rate