|
SNP/visible mold exposure
|
No. of asthma cases
|
Group size
|
aOR (95% CI)
|
AP
|
S
|
RERI
|
|---|
|
rs1042713/mold
| | | |
− 0.09 (− 0.70, 0.53)
|
0.86 (0.32, 2.35)
|
− 0.19 (− 1.51, 1.13)
|
|
AA/no
|
148
|
398
|
Ref
| | | |
|
GG + GA/no
|
309
|
779
|
1.13 (0.87, 1.47)
| | | |
|
AA/yes
|
42
|
73
|
2.23 (1.30, 3.86)*
| | | |
|
GG + GA/yes
|
109
|
197
|
2.17 (1.50, 3.15)*
| | | |
|
rs1042714/mold
| | | |
0.10 (− 0.51, 0.70)
|
1.23 (0.32, 4.70)
|
0.20 (− 1.15, 1.55)
|
|
CC/no
|
376
|
958
|
Ref
| | | |
|
GG + GC/no
|
81
|
219
|
0.91 (0.65, 1.25)
| | | |
|
CC/yes
|
120
|
217
|
1.96 (1.43, 2.70)*
| | | |
|
GG + GC/yes
|
31
|
53
|
2.07 (1.15, 3.79)*
| | | |
|
rs7216389/mold
| | | |
0.47 (0.03, 0.90)
|
3.08 (0.36, 26.06)
|
1.49 (0, 2.99)
|
|
CC/no
|
21
|
69
|
Ref
| | | |
|
TT + TC/no
|
436
|
1108
|
1.52 (0.88, 2.70)
| | | |
|
CC/yes
|
7
|
20
|
1.20 (0.38, 3.65)
| | | |
|
TT + TC/yes
|
144
|
250
|
3.21 (1.77, 5.99)*
| | | |
|
rs5498/mold
| | | |
− 0.16 (− 0.74, 0.43)
|
0.77 (0.31, 1.89)
|
− 0.34 (− 1.50, 0.83)
|
|
AA/no
|
220
|
592
|
Ref
| | | |
|
GG + GA/no
|
237
|
585
|
1.18 (0.92, 1.51)
| | | |
|
AA/yes
|
78
|
135
|
2.27 (1.52, 3.42)*
| | | |
|
GG + GA/yes
|
73
|
135
|
2.11 (1.41, 3.17)*
| | | |
|
rs1800925/mold
| | | |
0.35 (− 0.03, 0.74)
|
2.2 (0.75, 6.43)
|
1.01 (− 0.51, 2.53)
|
|
CC/no
|
318
|
834
|
Ref
| | | |
|
TT + CT/no
|
139
|
343
|
1.05 (0.79, 1.38)
| | | |
|
CC/yes
|
102
|
192
|
1.79 (1.28, 2.52)*
| | | |
|
TT + CT/yes
|
49
|
78
|
2.85 (1.72, 4.80)*
| | | |
|
rs2243250/mold
| | | |
− 0.03 (− 0.61, 0.55)
|
0.94 (0.25, 3.49)
|
− 0.05 (− 1.04, 0.94)
|
|
TT/no
|
321
|
792
|
Ref
| | | |
|
CC + CT/no
|
136
|
385
|
0.80 (0.61, 1.04)
| | | |
|
TT/yes
|
95
|
167
|
1.98 (1.38, 2.85)*
| | | |
|
CC + CT/yes
|
56
|
103
|
1.73 (1.12, 2.69)*
| | | |
|
rs1801275/mold
| | | |
− 0.20 (− 0.88, 0.47)
|
0.67 (0.19, 2.34)
|
− 0.35 (− 1.40, 0.70)
|
|
AA/no
|
334
|
849
|
Ref
| | | |
|
GG + GA/no
|
123
|
328
|
0.93 (0.70, 1.23)
| | | |
|
AA/yes
|
106
|
181
|
2.13 (1.51, 3.03)*
| | | |
|
GG + GA/yes
|
45
|
89
|
1.72 (1.08, 2.73)*
| | | |
|
rs324015/mold
| | | |
0.39 (− 0.04, 0.81)
|
5.79 (0.03, 1237.72)
|
0.73 (− 0.16, 1.61)
|
|
CC/no
|
142
|
336
|
Ref
| | | |
|
TT + CT/no
|
315
|
841
|
0.80 (0.61, 1.05)
| | | |
|
CC/yes
|
35
|
69
|
1.35 (0.78, 2.35)
| | | |
|
TT + CT/yes
|
116
|
201
|
1.88 (1.29, 2.74)*
| | | |
- SNP single nucleotide polymorphisms, Ref reference, aOR adjusted odds ratio, AP the attributable proportion due to interaction, S the synergy index, RERI the relative excess risk due to interaction
- Models were adjusted for age, gender, family history of allergy, parental education level, and ETS before and after birth
- *FDR adjusted p value < 0.05; FDR, False discovery rate
