| |
Minimally adjusteda
|
Adjustedb
|
|---|
|
Mean difference or odds ratio (95% CI)
|
P value
|
Mean difference or odds ratio (95% CI)
|
P value
|
|---|
|
Lung function
|
|
FEV%Pred
|
− 0.27
|
(− 2.70, 2.16)
|
0.828
|
− 2.51
|
(− 4.97, − 0.05)
|
0.046
|
|
COPD (OR)c
|
0.91
|
(0.74, 1.11)
|
0.333
|
1.20
|
(0.96, 1.50)
|
0.112
|
|
Quality of life/respiratory symptoms
|
|
CAT
|
2.38
|
(1.58, 3.18)
|
< 0.001
|
1.20
|
(0.40, 2.00)
|
0.003
|
|
mMRC
|
0.13
|
(0.03, 0.22)
|
0.012
|
0.06
|
(− 0.04, 0.16)
|
0.210
|
|
SGRQ total
|
5.70
|
(3.71, 7.70)
|
< 0.001
|
3.48
|
(1.49, 5.47)
|
0.001
|
|
6-min walk distance (meters)
|
− 16.0
|
(− 27.3, − 4.73)
|
0.005
|
− 12.7
|
(− 23.9, − 1.58)
|
0.025
|
|
Chest CT metric
|
|
% emphysema (− 950)
|
− 1.09
|
(− 2.07, − 0.12)
|
0.028
|
0.30
|
(− 0.58, 1.18)
|
0.508
|
|
% air trapping (− 856)
|
− 1.39
|
(− 3.46, 0.68)
|
0.187
|
2.47
|
(0.65, 4.29)
|
0.008
|
|
Exacerbations, last 12 months
|
|
Any (OR)c
|
1.42
|
(1.14, 1.76)
|
0.002
|
1.36
|
(1.08, 1.72)
|
0.010
|
|
Severe (OR)c
|
1.70
|
(1.27, 2.26)
|
< 0.001
|
1.56
|
(1.15, 2.13)
|
0.004
|
- Bold values indicate statistical significance at the p < 0.05 level
- aAdjusted by clinical centers
- bAdjusted for clinical centers, age, sex, race, education, income, marital status, rural status, BMI, smoking status, and pack years
- cCoefficient represents odds ratio
