A systematic review of the incidence, risk factors and prognosis of acute exacerbation of systemic autoimmune disease-associated interstitial lung disease

Table 4 Risk and prognostic factors of acute exacerbation of systemic autoimmune disease-associated interstitial lung disease by multivariate analysis

Potential risk factors^a	Study	Effect estimates (95% confidence interval)
Age	Suda [62]	HR 1.22 (1.05–1.50) (year) (at initial presentation)
DLCO (before acute exacerbation)	Manfredi [55]	HR 0.95 (0.90–1.00) (% of predicted value)
DLCO (before acute exacerbation)	Liang [54]	OR 0.97 (0.95–0.99) (% of predicted value)
Potential prognostic factors^a	Study	Effect estimates (95% confidence interval)
PaO₂/FiO₂ (at acute exacerbation)	Cao [49]	HR 0.99 (0.98–0.99)

Bold in text indicating statistical significance and risk or prognostic factors of acute exacerbation of systemic autoimmune disease-associated interstitial lung disease that were confirmed in this review
DLCO, diffusing capacity of the lung for carbon monoxide; HR, hazard ratio; OR, odds ratio; PaO₂/FiO₂, partial pressure of arterial oxygen/fraction of inspired oxygen ratio
^aAny clinical information that was reported in at least three studies

ISSN: 1471-2466