Table 6 Assessment of quality of evidence of risk and prognostic factors by the Grades of Recommendation, Assessment, Development and Evaluation (GRADE) system
GRADE factors | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Risk factorsa | Analysisb | Phase | Study limitations | Inconsistencyc | Indirectness | Publication bias | Imprecision | Moderate/large effect size | Dose response gradient | Overall quality |
Outcome: all-cause mortality | ||||||||||
Age | Uni | 1 | + | − | − | + | − | − | − | Low |
Multi | 1 | + | N/A | − | + | − | − | − | Very low | |
DLCO | Uni | 1 | + | + | − | + | − | + | − | Very Low |
Multi | 1 | + | − | − | + | − | − | − | Very low | |
GRADE factors | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Prognostic factorsa | Analysisb | Phase | Study limitations | Inconsistencyc | Indirectness | Publication bias | Imprecision | Moderate/large effect size | Dose response gradient | Overall quality |
Outcome: all-cause mortality | ||||||||||
PaO2/FiO2 | Uni | 1 | + | − | − | + | − | − | − | Very low |
Multi | 1 | + | N/A | − | + | − | − | − | Very low | |