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Table 5 Known checkpoints examined for expression and survival in MPM

From: Emerging avenues in immunotherapy for the management of malignant pleural mesothelioma

Gene

Alternative names

Altered expressiona (mRNA)

OSb (mRNA)

Comments

CD244

2B4

No

No

 

TNFRSF9

4-1BB

No

No

 

ANGPTL7

CDT6

No

No

 

CD80

B7-1

No

No

 

CD86

B7-2

No

No

 

ICOSLG

B7-H2

No

No

 

CD276

B7-H3

N/A

Yes

(p = 0.039)

High expression associated with poor OS

VTCN1

B7-H4

No

No

 

HHLA2

B7-H5

No

No

 

NCR3LG1

B7-H6

N/A

 

Not found in UALCAN

BTLA

 

N/A

No

 

BTN1A1

BTN

No

No

 

BTN3A1

CD277

Yes

(p = 0.029)

Yes

(p = 0.0093)

Upregulated in MPM

High expression associated with better OS

BTN3A3

BTF3

Yes

(p = 0.042)

Yes

(p = 0.0065)

Upregulated in MPM

High expression associated with better OS

PVR

CD155

No

Yes

(p = 0.023)

High expression associated with poor OS

CD160

BY55

No

No

 

LY9

CD229

No

No

 

CD28

Tp44

No

No

 

TNFRSF8

CD30

No

No

 

CD40

TNFRSF5

No

No

 

CD47

MER6, IAP

Yes

(p = 0.012)

No

Upregulated in MPM

CD48

BLAST1

No

No

 

CD84

SLAMF5

No

Yes

(p = 0.042)

High expression associated with poor OS

CD96

TACTILE

No

No

 

CTLA-4

CD152

No

No

 

CD226

DNAM-1

No

No

 

LGALS9

Galectin-9

No

No

 

TNFRSF18

GITR

N/A

No

 

TNFRSF14

HVEM

No

Yes

(p = 0.019)

High expression associated with better OS

TIM3

HAVCR2

No

No

 

ICOS

AILIM

No

No

 

LAG3

CD223

Yes

(p = 0.011)

Yes

(p = 0.021)

Upregulated in MPM

High expression associated with better OS

LAIR-1

 

No

No

 

LAIR-2

CD306

No

No

 

LILRA2

LIR7, CD85H

No

Yes

(p = 0.038)

High expression associated with better OS

LILRA3

LIR4, CD85E

No

No

 

LILRA5

LIR9, CD85F

No

No

 

LILRB1

LIR1, CD85

No

No

 

LILRB2

LIR2, CD85D

No

No

 

LILRB3

LIR3, CD85A

No

No

 

LILRB4

LIR5, CD85K

No

No

 

LILRB5

LIR8, CD85C

No

No

 

Nectin-1

PVRL1

No

Yes

(p = 0.0042)

High expression associated with poor OS

Nectin-2

PVRL2

No

No

 

Nectin-3

PVRL3

Yes

(p = 0.012)

Yes

(p = 0.024)

Upregulated in MPM

High expression associated with poor OS

NCR3

NKp30

No

No

 

SLAMF6

NTB-A

N/A

No

 

OX40

TNFRSF4

No

No

 

OX40L

TNFSF4

Yes

(p = 0.047)

Yes

(p = 0.00018)

High expression associated with poor OS

PD1

CD279

No

No

 

PD-L1

CD274

N/A

No

 

PD-L2

B7DC

No

No

 

PVRIG

CD112R

No

No

 

SIRPA

PTPNS1

No

Yes

(p = 0.0091)

High expression associated with better OS

SIRPG

SIRP gamma

No

No

 

SIRPB1

SIRP-beta 1

Yes

(p = 7.92 × 10–7)

No

Upregulated in MPM

SIRPB2

 

N/A

No

 

SLAMF1

CD150

No

No

 

SLAMF7

CD319

No

No

 

TIGIT

 

N/A

No

 

VISTA

VSIR, C10ORF54

N/A

Yes

(p = 0.00093)

High expression associated with better OS

VSIG3

IGSF11

N/A

No

Ligand of VISTA

VSIG4

CRIG

No

No

 
  1. Bold value represents significance at p < 0.05
  2. aAssessed using oncomine analysis [76] of the Gordon MPM dataset (normal pleura versus malignant) [77]
  3. bAssessed using UALCAN [78]