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Table 5 Known checkpoints examined for expression and survival in MPM

From: Emerging avenues in immunotherapy for the management of malignant pleural mesothelioma

Gene Alternative names Altered expressiona (mRNA) OSb (mRNA) Comments
CD244 2B4 No No  
TNFRSF9 4-1BB No No  
ANGPTL7 CDT6 No No  
CD80 B7-1 No No  
CD86 B7-2 No No  
ICOSLG B7-H2 No No  
CD276 B7-H3 N/A Yes
(p = 0.039)
High expression associated with poor OS
VTCN1 B7-H4 No No  
HHLA2 B7-H5 No No  
NCR3LG1 B7-H6 N/A   Not found in UALCAN
BTLA   N/A No  
BTN1A1 BTN No No  
BTN3A1 CD277 Yes
(p = 0.029)
Yes
(p = 0.0093)
Upregulated in MPM
High expression associated with better OS
BTN3A3 BTF3 Yes
(p = 0.042)
Yes
(p = 0.0065)
Upregulated in MPM
High expression associated with better OS
PVR CD155 No Yes
(p = 0.023)
High expression associated with poor OS
CD160 BY55 No No  
LY9 CD229 No No  
CD28 Tp44 No No  
TNFRSF8 CD30 No No  
CD40 TNFRSF5 No No  
CD47 MER6, IAP Yes
(p = 0.012)
No Upregulated in MPM
CD48 BLAST1 No No  
CD84 SLAMF5 No Yes
(p = 0.042)
High expression associated with poor OS
CD96 TACTILE No No  
CTLA-4 CD152 No No  
CD226 DNAM-1 No No  
LGALS9 Galectin-9 No No  
TNFRSF18 GITR N/A No  
TNFRSF14 HVEM No Yes
(p = 0.019)
High expression associated with better OS
TIM3 HAVCR2 No No  
ICOS AILIM No No  
LAG3 CD223 Yes
(p = 0.011)
Yes
(p = 0.021)
Upregulated in MPM
High expression associated with better OS
LAIR-1   No No  
LAIR-2 CD306 No No  
LILRA2 LIR7, CD85H No Yes
(p = 0.038)
High expression associated with better OS
LILRA3 LIR4, CD85E No No  
LILRA5 LIR9, CD85F No No  
LILRB1 LIR1, CD85 No No  
LILRB2 LIR2, CD85D No No  
LILRB3 LIR3, CD85A No No  
LILRB4 LIR5, CD85K No No  
LILRB5 LIR8, CD85C No No  
Nectin-1 PVRL1 No Yes
(p = 0.0042)
High expression associated with poor OS
Nectin-2 PVRL2 No No  
Nectin-3 PVRL3 Yes
(p = 0.012)
Yes
(p = 0.024)
Upregulated in MPM
High expression associated with poor OS
NCR3 NKp30 No No  
SLAMF6 NTB-A N/A No  
OX40 TNFRSF4 No No  
OX40L TNFSF4 Yes
(p = 0.047)
Yes
(p = 0.00018)
High expression associated with poor OS
PD1 CD279 No No  
PD-L1 CD274 N/A No  
PD-L2 B7DC No No  
PVRIG CD112R No No  
SIRPA PTPNS1 No Yes
(p = 0.0091)
High expression associated with better OS
SIRPG SIRP gamma No No  
SIRPB1 SIRP-beta 1 Yes
(p = 7.92 × 10–7)
No Upregulated in MPM
SIRPB2   N/A No  
SLAMF1 CD150 No No  
SLAMF7 CD319 No No  
TIGIT   N/A No  
VISTA VSIR, C10ORF54 N/A Yes
(p = 0.00093)
High expression associated with better OS
VSIG3 IGSF11 N/A No Ligand of VISTA
VSIG4 CRIG No No  
  1. Bold value represents significance at p < 0.05
  2. aAssessed using oncomine analysis [76] of the Gordon MPM dataset (normal pleura versus malignant) [77]
  3. bAssessed using UALCAN [78]