Fig. 1

TUDCA attenuates BLM-induced histological damage and collagen deposition in the mice lungs. In BLM alone and BLM + TUDCA group, mice were intratracheally injected with a single dose of BLM (3.0 mg/kg). In TUDCA alone and BLM + TUDCA group, mice were intraperitoneally injected with TUDCA (250 mg/kg) once a day. Mice were intraperitoneally injected with NS and administered with NS by intratracheal injection in control group. Mice were sacrificed at 21 d after BLM treatment. a Pulmonary tissues were stained with H&E. Original magnification: 100×. b Pathological damage degree was assessed. c Pulmonary tissues were stained with Sirius Red. Original magnification: 100×. d Quantification of collagen deposition area. e The levels of hydroxyproline were detected in mice lungs. All data were expressed as means ± S.E.M. (pathological damage degree and levels of hydroxyproline) or median (IQR) (collagen deposition area) of ten lung tissues from ten different mice