Fig. 6

TUDCA blocks BLM-induced ER stress in the lungs. In BLM alone and BLM + TUDCA group, mice were intratracheally injected with a single dose of BLM (3.0 mg/kg). In TUDCA alone and BLM + TUDCA group, mice were intraperitoneally injected with TUDCA (250 mg/kg) once a day. Mice were intraperitoneally injected with NS and administered with NS by intratracheal injection in control group. Mice were sacrificed at 21 d after BLM treatment. a Pulmonary GRP78 and CHOP were detected via immunoblot. b, c Quantitative analysis of grayscale value. All data were expressed as means ± S.E.M. (CHOP) or median (IQR) (GRP78) of ten lung tissues from ten different mice