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Table 1 Characteristics comparison between positive TBLB and negative TBLB patients

From: The value of transbronchial lung biopsy in the diagnosis of lymphangioleiomyomatosis

Characteristics Total
TBLB
N = 86
Positive
TBLB
N = 49
Negative
TBLB
N = 37
P value
Age, mean ± SD 42 ± 9 42 ± 9 41 ± 8 0.554
Definite LAM, N (%) 74 (86.0) 49 (100) 25 (67.6)  < 0.001
AML, N (%) 11 (12.8) 7 (14.3) 4 (10.8) 0.879
Chylothorax, N (%) 9 (10.5) 6 (12.2) 3 (8.1) 0.791
Chylous ascites, N (%) 1 (1.2) 1 (2.0) 0 (0) 1.000
Lymphangioleiomyoma, n/N (%) 26/77 (33.8) 16 (36.4) 10 (30.3) 0.574
VEGF-D > 800, n/N (%) 57/76 (75.0) 36/43 (83.7) 21/33 (63.6) 0.045
CT grade n = 76 n = 43 n = 33  
I, N (%) 15 (19.7) 6 (14.0) 9 (27.3) 0.147
II, N (%) 10 (13.2) 6 (14.0) 4 (12.1) 1.000
III, N (%) 51 (67.1) 31 (72.0) 20 (60.6) 0.291
NO. of biopsy specimens n = 61 n = 37 n = 24  
1–2 specimens, N (%) 7 (11.5) 1 (2.7) 6 (25.0) 0.024
3–4 specimens, N (%) 46 (75.4) 29 (78.4) 17 (70.8) 0.504
5–6 specimens, N (%) 8 (13.1) 7 (18.9) 1 (4.2) 0.201
Immunohistochemical
SMA, n/N (%) 53/57 (93.0) 40/41 (97.6) 13/16 (81.25) 0.112
HMB-45, n/N (%) 40/60 (66.7) 40/43 (93.0) 0/17 (0)  < 0.001
ER, n/N (%) 38/50 (76) 33/39 (84.6) 5/11 (45.5) 0.022
PR, n/N (%) 34/48 (70.8) 29/37 (78.4) 5/11 (45.5) 0.083
  1. Bold values indicate P < 0.05 was considered significant
  2. AML: angiomyolipoma; CT: computed tomography; ER: estrogen receptor; PR: progesterone receptor; SMA: smooth muscle actin; TBLB: transbronchial lung biopsy; VEGF-D: vascular endothelial growth factor-D
  3. The P value was calculated using Pearson's chi-square test
  4. The P value was calculated with the use of the unpaired t-test