Table 1 Characteristics comparison between positive TBLB and negative TBLB patients
From: The value of transbronchial lung biopsy in the diagnosis of lymphangioleiomyomatosis
Characteristics | Total TBLB N = 86 | Positive TBLB N = 49 | Negative TBLB N = 37 | P value |
|---|---|---|---|---|
Age, mean ± SD | 42 ± 9 | 42 ± 9 | 41 ± 8 | 0.554¶ |
Definite LAM, N (%) | 74 (86.0) | 49 (100) | 25 (67.6) | < 0.001 |
AML, N (%) | 11 (12.8) | 7 (14.3) | 4 (10.8) | 0.879 |
Chylothorax, N (%) | 9 (10.5) | 6 (12.2) | 3 (8.1) | 0.791 |
Chylous ascites, N (%) | 1 (1.2) | 1 (2.0) | 0 (0) | 1.000 |
Lymphangioleiomyoma, n/N (%) | 26/77 (33.8) | 16 (36.4) | 10 (30.3) | 0.574 |
VEGF-D > 800, n/N (%) | 57/76 (75.0) | 36/43 (83.7) | 21/33 (63.6) | 0.045 |
CT grade | n = 76 | n = 43 | n = 33 | |
I, N (%) | 15 (19.7) | 6 (14.0) | 9 (27.3) | 0.147 |
II, N (%) | 10 (13.2) | 6 (14.0) | 4 (12.1) | 1.000 |
III, N (%) | 51 (67.1) | 31 (72.0) | 20 (60.6) | 0.291 |
NO. of biopsy specimens | n = 61 | n = 37 | n = 24 | |
1–2 specimens, N (%) | 7 (11.5) | 1 (2.7) | 6 (25.0) | 0.024 |
3–4 specimens, N (%) | 46 (75.4) | 29 (78.4) | 17 (70.8) | 0.504 |
5–6 specimens, N (%) | 8 (13.1) | 7 (18.9) | 1 (4.2) | 0.201 |
Immunohistochemical | ||||
SMA, n/N (%) | 53/57 (93.0) | 40/41 (97.6) | 13/16 (81.25) | 0.112 |
HMB-45, n/N (%) | 40/60 (66.7) | 40/43 (93.0) | 0/17 (0) | < 0.001 |
ER, n/N (%) | 38/50 (76) | 33/39 (84.6) | 5/11 (45.5) | 0.022 |
PR, n/N (%) | 34/48 (70.8) | 29/37 (78.4) | 5/11 (45.5) | 0.083 |