Prognostic marker for severe acute exacerbation of chronic obstructive pulmonary disease: analysis of diffusing capacity of the lung for carbon monoxide (DLCO) and forced expiratory volume in one second (FEV1)

Table 4 ROC curve analysis of D_LCO, FEV₁, and D_LCO + FEV₁

Parameter	Prognostic factor	Optimal cut-off	Sensitivity	Specificity	AUC	95% confidence interval	P value
Mortality in hospital	D_LCO	48.5	71.0	72.7	0.827	0.749–0.905	< 0.001
	FEV₁	45.5	63.1	63.6	0.621	0.481–0.760	0.173
	D_LCO + FEV₁	47.25	72.7	71.9	0.759	0.649–0.870	0.003
Mechanical ventilation	D_LCO	51.5	68.4	65.5	0.717	0.629–0.804	< 0.001
	FEV₁	44.5	66.5	65.5	0.675	0.566–0.784	0.002
	D_LCO + FEV₁	50.25	69.0	68.7	0.714	0.612–0.816	< 0.001
Intensive care unit	D_LCO	53.5	65.0	64.1	0.682	0.602–0.762	< 0.001
	FEV₁	46.5	63.0	64.1	0.652	0.560–0.743	0.002
	D_LCO + FEV₁	50.25	64.1	69.3	0.684	0.597–0.771	< 0.001

ROC receiver operating characteristics, AUC area under the curve, FEV₁ forced expiratory volume in one second, D_LCO diffusing capacity of the lung for carbon monoxide

ISSN: 1471-2466