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Table 2 Baseline and 1 year follow up data for patients within mild group (those with matched tests)

From: A role for cardiopulmonary exercise testing in detecting physiological changes underlying health status in Idiopathic pulmonary fibrosis: a feasibility study

CPET parameters

Baseline (n = 13)

Follow up (n = 13)

p value

VO2 peak (ml/kg/min)

21.6 ± 2.9

19.1 ± 2.8

0.017

VO2 peak at AT (ml/kg/min)

14.2 ± 3.2

11.8 ± 1.6, n = 12

0.044

VE peak (L/min)

75.3 ± 20.9

66.1 ± 21.6

0.007

VE peak % pred

75.5 ± 13.2

65.9 ± 12.2

0.007

VE/VCO2 at AT

29.7 ± 3.1

31 ± 4.6, n = 12

0.353

Minimum O2 saturation during CPET (%)

91.5 ± 5.5

87.9 ± 6.6, n = 12

0.182

Peak Work (W)

106.9 ± 26.3

90.8 ± 25.9

0.022

Peak Work (% predicted)

44.3 ± 6.9

37.7 ± 8.5

0.002

HR (bpm)

142.3 ± 24.0

133 ± 22.3

0.040

HR (% predicted)

98.7 ± 16.9

91.8 ± 16.8

0.022

BR max (L/min)(median, (IQR))

21.8 (12.4–34.2)

33.8 (20.2–55.7)

0.0002

6MWT

   

 Distance achieved (m)

346.9 ± 73.8

340.8 ± 72.4

0.563

 % theoretical distance (m)

76.4 ± 18.3

76.0 ± 16.8

0.872

Lung function

   

 FVC % predicted

98.8 ± 8.5

93.4 ± 10.3

0.010

 TLco % predicted

62.3 ± 9.4

59.3 ± 11.8

0.161

  1. VO2 peak peak oxygen consumption/kg; AT anaerobic threshold; VE minute ventilation; VCO2 carbon dioxide output; VCO2 ventilatory equivalent for carbon dioxide; VE/VCO2 BR max breathing reserve; W work; bpm beats per minute; % percentage; IQR interquartile range; n number; 6MWT 6 min walk test; FVC Forced Vital Capacity; TLco transfer factor; m metres; % percentage; CPET cardiopulmonary exercise testing. All values are shown as mean ± standard deviation, unless otherwise stated. Paired t-test was used for parametric data, whilst Wilcoxon matched pairs signed rank test was used for non-parametric data. A p < 0.05 was considered statistically significant