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Table 2 Baseline and 1 year follow up data for patients within mild group (those with matched tests)

From: A role for cardiopulmonary exercise testing in detecting physiological changes underlying health status in Idiopathic pulmonary fibrosis: a feasibility study

CPET parameters Baseline (n = 13) Follow up (n = 13) p value
VO2 peak (ml/kg/min) 21.6 ± 2.9 19.1 ± 2.8 0.017
VO2 peak at AT (ml/kg/min) 14.2 ± 3.2 11.8 ± 1.6, n = 12 0.044
VE peak (L/min) 75.3 ± 20.9 66.1 ± 21.6 0.007
VE peak % pred 75.5 ± 13.2 65.9 ± 12.2 0.007
VE/VCO2 at AT 29.7 ± 3.1 31 ± 4.6, n = 12 0.353
Minimum O2 saturation during CPET (%) 91.5 ± 5.5 87.9 ± 6.6, n = 12 0.182
Peak Work (W) 106.9 ± 26.3 90.8 ± 25.9 0.022
Peak Work (% predicted) 44.3 ± 6.9 37.7 ± 8.5 0.002
HR (bpm) 142.3 ± 24.0 133 ± 22.3 0.040
HR (% predicted) 98.7 ± 16.9 91.8 ± 16.8 0.022
BR max (L/min)(median, (IQR)) 21.8 (12.4–34.2) 33.8 (20.2–55.7) 0.0002
6MWT    
 Distance achieved (m) 346.9 ± 73.8 340.8 ± 72.4 0.563
 % theoretical distance (m) 76.4 ± 18.3 76.0 ± 16.8 0.872
Lung function    
 FVC % predicted 98.8 ± 8.5 93.4 ± 10.3 0.010
 TLco % predicted 62.3 ± 9.4 59.3 ± 11.8 0.161
  1. VO2 peak peak oxygen consumption/kg; AT anaerobic threshold; VE minute ventilation; VCO2 carbon dioxide output; VCO2 ventilatory equivalent for carbon dioxide; VE/VCO2 BR max breathing reserve; W work; bpm beats per minute; % percentage; IQR interquartile range; n number; 6MWT 6 min walk test; FVC Forced Vital Capacity; TLco transfer factor; m metres; % percentage; CPET cardiopulmonary exercise testing. All values are shown as mean ± standard deviation, unless otherwise stated. Paired t-test was used for parametric data, whilst Wilcoxon matched pairs signed rank test was used for non-parametric data. A p < 0.05 was considered statistically significant