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Fig. 1 | BMC Pulmonary Medicine

Fig. 1

From: Long non-coding RNA GATA6-AS1 upregulates GATA6 to regulate the biological behaviors of lung adenocarcinoma cells

Fig. 1

The downregulated GATA6-AS1 suppressed the proliferation and migration, as well as induced the apoptosis of LUAD. a GATA6-AS1 expression in 483 LUAD tissues and 437 adjacent normal tissues was indicated from GEPIA database. b Expression of GATA6-AS1 in 35 LUAD tissues and non-tumor tissues was detected by RT-qPCR. c RT-qPCR revealed the expression of GATA6-AS1 in LUAD cells and human lung cells. d The overexpression efficiency of GATA6-AS1 was depicted through RT-qPCR. e The EdU assay was performed to evaluate effects of upregulated GATA6-AS1 on proliferative ability of A549 and H1975 cells. f, g The colony formation assay demonstrated cell proliferation after transfection with overexpressed GATA6-AS1. h The influence of GATA6-AS1 overexpression on the apoptosis of LUAD cells was examined by the TUNEL assay. i Flow cytometric analysis depicted the apoptotic rate of A549 and H1975 cells upon the upregulation of GATA6-AS1. jk The wound healing assay was conducted to determine cell migration affected by overexpressed GATA6-AS1. l Transwell assay was performed to reveal invasion of LUAD cells transfected with pcDNA3.1 or pcDNA3.1-GATA6-AS1. *p < 0.05, **p < 0.01

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