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Fig. 5 | BMC Pulmonary Medicine

Fig. 5

From: NAPG mutation in family members with hereditary hemorrhagic telangiectasia in China

Fig. 5

Tertiary structure prediction of NAPG and hydrogen bond changes after MET262VAL mutation. A, A cartoon representation of the human NAPG structure in the rainbow coloring scheme from the N-terminal (blue) to the Carboxyl-terminal (red); the blue arrow indicates MET262VAL. B, Hydrogen bonds in wild-type NAPG. C, Hydrogen bonds in NAPG p.262 M > V. Green dotted lines indicate hydrogen bonds. Numbers indicate hydrogen bond distances. The orange arrow indicates a hydrogen bond loss between PHE259 and VAL262. The blue arrows indicate new hydrogen bond formations between ASP263 and ASP265, and between ASN264 and ALA267

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