Table 1 The baseline data and prognosis of patients with hypoxemia of different severities in the two groups after PSM
100 < PaO2/FiO2 ≤ 300 n = 801 | 100 < PaO2/FiO2 ≤ 200 n = 315 | 200 < PaO2/FiO2 ≤ 300 n = 486 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
After PSM n = 466 | Treatment group n = 233 | Control group n = 233 | P value | After PSM n = 190 | Treatment group n = 95 | Control group n = 95 | P value | After PSM l n = 304 | Treatment group n = 152 | Control group n = 152 | P | |
Age, median [Q1, Q3] | 69.38[61.00, 77.59] | 68.74[59.90, 77.81] | 69.80[61.48, 76.32] | 0.850 | 70.06[60.32, 78.09] | 69.91[60.55, 77.58] | 70.80[59.47, 78.50] | 0.638 | 68.09[59.57, 75.49] | 66.79[58.59, 75.85] | 68.71[60.21, 75.22] | 0.391 |
Male, n (%) | 322(69.10) | 158(67.81) | 164(70.39) | 0.616 | 126(66.32) | 62(65.26) | 64(67.37) | 0.878 | 195(64.14) | 92(60.53) | 103(67.76) | 0.232 |
BMI, mean (SD) | 31.93(6.56) | 32.04(6.60) | 31.81(6.53) | 0.708 | 33.85(6.47) | 33.38(6.34) | 34.34(6.61) | 0.322 | 31.51(7.33) | 31.09(6.93) | 31.94(7.72) | 0.330 |
Baseline disease | ||||||||||||
Hypertension, n (%) | 316(67.81) | 157(67.38) | 159(68.24) | 0.921 | 123(64.74) | 59(62.11) | 64(67.37) | 0.544 | 188(61.84) | 92(60.53) | 96(63.16) | 0.723 |
Diabetes mellitus, n (%) | 88(18.88) | 47(20.17) | 41(17.60) | 0.554 | 30(15.79) | 15(15.79) | 15(15.79) | 1.000 | 57(18.75) | 32(21.05) | 25(16.45) | 0.378 |
COPD, n (%) | 52(11.16) | 29(12.45) | 23(9.87) | 0.462 | 17(8.95) | 12(12.63) | 5(5.26) | 0.127 | 35(11.51) | 18(11.84) | 17(11.18) | 1.000 |
Congestive heart failure, n (%) | 133(28.54) | 62(26.61) | 71(30.47) | 0.412 | 51(26.84) | 20(21.05) | 31(32.63) | 0.102 | 79(25.99) | 39(25.66) | 40(26.32) | 1.000 |
Myocardial infarction, n (%) | 54(11.59) | 28(12.02) | 26(11.16) | 0.885 | 25(13.16) | 11(11.58) | 14(14.74) | 0.668 | 36(11.84) | 19(12.50) | 17(11.18) | 0.859 |
Chronic kidney disease, n (%) | 96(20.60) | 51(21.89) | 45(19.31) | 0.567 | 35(18.42) | 15(15.79) | 20(21.05) | 0.454 | 60(19.74) | 33(21.71) | 27(17.76) | 0.471 |
Leukaemia, n (%) | 3(0.64) | 1(0.43) | 2(0.86) | 1.000 | 6(3.16) | 2(2.11) | 4(4.21) | 0.682 | 3(0.99) | 1(0.66) | 2(1.32) | 1.000 |
Strokes, n (%) | 20(4.29) | 11(4.72) | 9(3.86) | 0.819 | 5(2.63) | 2(2.11) | 3(3.16) | 1.000 | 20(6.58) | 13(8.55) | 7(4.61) | 0.247 |
Cancer, n (%) | 48(10.30) | 25(10.73) | 23(9.87) | 0.879 | 25(13.16) | 16(16.84) | 9(9.47) | 0.198 | 33(10.86) | 15(9.87) | 18(11.84) | 0.712 |
Liver disease, n (%) | 32(6.87) | 14(6.01) | 18(7.73) | 0.583 | 12(6.32) | 9(9.47) | 3(3.16) | 0.136 | 32(10.53) | 20(13.16) | 12(7.89) | 0.191 |
SAPS-II at admission, mean (SD) | 42.99(12.44) | 43.00(12.96) | 42.97(11.92) | 0.979 | 43.17(13.09) | 43.42(13.60) | 42.93(12.62) | 0.795 | 42.61(12.97) | 43.12(13.54) | 42.09(12.39) | 0.491 |
Duration before extubation, median [Q1,Q3], hours | 20.77[6.89, 65.71] | 22.00[7.32, 73.27] | 19.50[6.12, 48.85] | 0.136 | 21.73[6.68, 57.68] | 24.00[6.73, 68.37] | 20.47[6.76, 47.30] | 0.304 | 19.78[6.91, 81.10] | 21.99[7.24, 108.54] | 18.08[6.35, 46.92] | 0.133 |
Physiological variables before extubation 4 h | ||||||||||||
Heart rate, mean (SD) | 83.15(13.84) | 83.74(13.97) | 82.55(13.72) | 0.354 | 82.93(13.39) | 82.72(12.30) | 83.14(14.47) | 0.832 | 83.94(13.47) | 84.72(14.41) | 83.17(12.47) | 0.316 |
Respiratory rate, mean (SD) | 18.99(3.95) | 19.07(3.90) | 18.91(4.00) | 0.669 | 19.37(3.97) | 19.40(4.06) | 19.35(3.90) | 0.938 | 18.81(3.97) | 18.90(4.09) | 18.73(3.86) | 0.701 |
Tidal volume, mean (SD) | 487.80(125.50) | 493.81(127.26) | 481.81(123.75) | 0.337 | 504.61(134.40) | 521.13(139.12) | 487.07(127.73) | 0.101 | 487.71(122.32) | 487.63(124.30) | 487.79(120.82) | 0.991 |
MBP, mean (SD) | 77.51(11.00) | 77.80(11.62) | 77.22(10.35) | 0.570 | 77.91(10.51) | 78.35(10.40) | 77.46(10.65) | 0.562 | 78.46(12.22) | 78.83(13.21) | 78.08(11.16) | 0.591 |
pH, mean (SD) | 7.40(0.05) | 7.40(0.05) | 7.39(0.05) | 0.366 | 7.40(0.06) | 7.40(0.06) | 7.40(0.05) | 0.358 | 7.39(0.05) | 7.39(0.05) | 7.39(0.05) | 0.812 |
PaO2, median [Q1, Q3] | 100.00[84.00, 115.00] | 97.75[83.00, 114.00] | 101.50[86.00, 118.00] | 0.208 | 84.42[76.25, 95.00] | 84.50[78.75, 95.00] | 84.33[76.00, 95.25] | 0.924 | 109.00[98.88, 125.63] | 107.00[95.38, 122.56] | 110[100.50, 130.63] | 0.340 |
PaCO2, mean (SD) | 41.01(6.96) | 40.75(6.57) | 41.26(7.34) | 0.433 | 40.70[6.56] | 40.61[6.12] | 40.79[7.01] | 0.852 | 41.08(6.65) | 40.78(6.98) | 41.37(6.32) | 0.441 |
SpO2, median [Q1, Q3] | 97.50[95.83, 98.75] | 97.25[95.80, 98.75] | 97.50[96.00, 99.00] | 0.397 | 96.06[94.68, 97.79] | 95.75[94.50, 97.52] | 96.50[94.90, 98.20] | 0.152 | 98.00[96.67, 99.25] | 97.75[96.75, 99.16] | 98.25[96.50, 99.25] | 0.412 |
PaO2/FiO2, median [Q1,Q3] | 211.79[171.42, 253.23] | 209.00[164.00, 253.62] | 213.00[179.33, 253.06] | 0.253 | 169.46[155.08, 182.83] | 166.67[157.44, 180.60] | 171.33[153.44, 187.56] | 0.283 | 242.00[217.50, 270.23] | 238.46[214.00, 267.34] | 248.04[222.00, 273.98] | 0.209 |
Reintubation 48 h, n (%) | 57(12.23) | 20(8.58) | 37(15.88) | 0.024 | 24(12.63) | 8(8.42) | 16(16.84) | 0.126 | 37(12.17) | 15(9.87) | 22(14.47) | 0.293 |
Reintubation 28 days, n (%) | 97(20.82) | 46(19.74) | 51(21.89) | 0.648 | 39(20.53) | 16(16.84) | 23(24.21) | 0.281 | 67(22.04) | 38(25.00) | 29(19.08) | 0.268 |
Mortality 28 days, n (%) | 22(4.72) | 10(4.29) | 12(5.15) | 0.827 | 7(3.68) | 3(3.16) | 4(4.21) | 1.000 | 21(6.91) | 12(7.89) | 9(5.92) | 0.651 |
Duration before reintubation, median [Q1, Q3], hours | 28.65[11.57, 90.78] | 73.28[21.63, 124.15] | 21.52[8.84, 56.85] | 0.001 | 25.03[9.04, 113.43] | 52.22[5.96, 163.10] | 21.72[10.88, 66.22] | 0.424 | 38.55[12.12, 111.62] | 73.66[27.39, 133.14] | 19.70[4.62, 40.63] | 0.001 |
LOS in hospital, median [Q1, Q3] | 11.54[7.18, 17.75] | 12.62[7.65, 20.61] | 10.93[6.83, 15.82] | 0.001 | 11.87[7.65, 16.61] | 12.80[7.79, 19.23] | 11.28[7.48, 15.43] | 0.102 | 12.01[7.02, 19.90] | 14.59[8.68, 25.02] | 10.12[6.22, 16.72] | < 0.001 |
LOS in ICU, median [Q1, Q3] | 5.55[3.09, 11.14] | 6.36[3.85, 13.59] | 4.72[2.27, 9.70] | < 0.001 | 5.39[3.10, 10.93] | 6.22[3.82, 12.69] | 4.80[2.30, 9.39] | 0.026 | 6.19[3.12, 13.14] | 7.43[4.19, 15.89] | 4.25[2.23, 9.47] | < 0.001 |