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Table 1 The baseline data and prognosis of patients with hypoxemia of different severities in the two groups after PSM

From: Effects of high-flow oxygen therapy on patients with hypoxemia after extubation and predictors of reintubation: a retrospective study based on the MIMIC-IV database

  100 < PaO2/FiO2 ≤ 300 n = 801 100 < PaO2/FiO2 ≤ 200 n = 315 200 < PaO2/FiO2 ≤ 300 n = 486
  After PSM n = 466 Treatment group n = 233 Control group n = 233 P value After PSM n = 190 Treatment group n = 95 Control group n = 95 P value After PSM l n = 304 Treatment group n = 152 Control group n = 152 P
Age, median [Q1, Q3] 69.38[61.00, 77.59] 68.74[59.90, 77.81] 69.80[61.48, 76.32] 0.850 70.06[60.32, 78.09] 69.91[60.55, 77.58] 70.80[59.47, 78.50] 0.638 68.09[59.57, 75.49] 66.79[58.59, 75.85] 68.71[60.21, 75.22] 0.391
Male, n (%) 322(69.10) 158(67.81) 164(70.39) 0.616 126(66.32) 62(65.26) 64(67.37) 0.878 195(64.14) 92(60.53) 103(67.76) 0.232
BMI, mean (SD) 31.93(6.56) 32.04(6.60) 31.81(6.53) 0.708 33.85(6.47) 33.38(6.34) 34.34(6.61) 0.322 31.51(7.33) 31.09(6.93) 31.94(7.72) 0.330
Baseline disease
 Hypertension, n (%) 316(67.81) 157(67.38) 159(68.24) 0.921 123(64.74) 59(62.11) 64(67.37) 0.544 188(61.84) 92(60.53) 96(63.16) 0.723
 Diabetes mellitus, n (%) 88(18.88) 47(20.17) 41(17.60) 0.554 30(15.79) 15(15.79) 15(15.79) 1.000 57(18.75) 32(21.05) 25(16.45) 0.378
 COPD, n (%) 52(11.16) 29(12.45) 23(9.87) 0.462 17(8.95) 12(12.63) 5(5.26) 0.127 35(11.51) 18(11.84) 17(11.18) 1.000
 Congestive heart failure, n (%) 133(28.54) 62(26.61) 71(30.47) 0.412 51(26.84) 20(21.05) 31(32.63) 0.102 79(25.99) 39(25.66) 40(26.32) 1.000
 Myocardial infarction, n (%) 54(11.59) 28(12.02) 26(11.16) 0.885 25(13.16) 11(11.58) 14(14.74) 0.668 36(11.84) 19(12.50) 17(11.18) 0.859
 Chronic kidney disease, n (%) 96(20.60) 51(21.89) 45(19.31) 0.567 35(18.42) 15(15.79) 20(21.05) 0.454 60(19.74) 33(21.71) 27(17.76) 0.471
 Leukaemia, n (%) 3(0.64) 1(0.43) 2(0.86) 1.000 6(3.16) 2(2.11) 4(4.21) 0.682 3(0.99) 1(0.66) 2(1.32) 1.000
 Strokes, n (%) 20(4.29) 11(4.72) 9(3.86) 0.819 5(2.63) 2(2.11) 3(3.16) 1.000 20(6.58) 13(8.55) 7(4.61) 0.247
 Cancer, n (%) 48(10.30) 25(10.73) 23(9.87) 0.879 25(13.16) 16(16.84) 9(9.47) 0.198 33(10.86) 15(9.87) 18(11.84) 0.712
 Liver disease, n (%) 32(6.87) 14(6.01) 18(7.73) 0.583 12(6.32) 9(9.47) 3(3.16) 0.136 32(10.53) 20(13.16) 12(7.89) 0.191
 SAPS-II at admission, mean (SD) 42.99(12.44) 43.00(12.96) 42.97(11.92) 0.979 43.17(13.09) 43.42(13.60) 42.93(12.62) 0.795 42.61(12.97) 43.12(13.54) 42.09(12.39) 0.491
 Duration before extubation, median [Q1,Q3], hours 20.77[6.89, 65.71] 22.00[7.32, 73.27] 19.50[6.12, 48.85] 0.136 21.73[6.68, 57.68] 24.00[6.73, 68.37] 20.47[6.76, 47.30] 0.304 19.78[6.91, 81.10] 21.99[7.24, 108.54] 18.08[6.35, 46.92] 0.133
Physiological variables before extubation 4 h
 Heart rate, mean (SD) 83.15(13.84) 83.74(13.97) 82.55(13.72) 0.354 82.93(13.39) 82.72(12.30) 83.14(14.47) 0.832 83.94(13.47) 84.72(14.41) 83.17(12.47) 0.316
 Respiratory rate, mean (SD) 18.99(3.95) 19.07(3.90) 18.91(4.00) 0.669 19.37(3.97) 19.40(4.06) 19.35(3.90) 0.938 18.81(3.97) 18.90(4.09) 18.73(3.86) 0.701
 Tidal volume, mean (SD) 487.80(125.50) 493.81(127.26) 481.81(123.75) 0.337 504.61(134.40) 521.13(139.12) 487.07(127.73) 0.101 487.71(122.32) 487.63(124.30) 487.79(120.82) 0.991
 MBP, mean (SD) 77.51(11.00) 77.80(11.62) 77.22(10.35) 0.570 77.91(10.51) 78.35(10.40) 77.46(10.65) 0.562 78.46(12.22) 78.83(13.21) 78.08(11.16) 0.591
 pH, mean (SD) 7.40(0.05) 7.40(0.05) 7.39(0.05) 0.366 7.40(0.06) 7.40(0.06) 7.40(0.05) 0.358 7.39(0.05) 7.39(0.05) 7.39(0.05) 0.812
 PaO2, median [Q1, Q3] 100.00[84.00, 115.00] 97.75[83.00, 114.00] 101.50[86.00, 118.00] 0.208 84.42[76.25, 95.00] 84.50[78.75, 95.00] 84.33[76.00, 95.25] 0.924 109.00[98.88, 125.63] 107.00[95.38, 122.56] 110[100.50, 130.63] 0.340
 PaCO2, mean (SD) 41.01(6.96) 40.75(6.57) 41.26(7.34) 0.433 40.70[6.56] 40.61[6.12] 40.79[7.01] 0.852 41.08(6.65) 40.78(6.98) 41.37(6.32) 0.441
 SpO2, median [Q1, Q3] 97.50[95.83, 98.75] 97.25[95.80, 98.75] 97.50[96.00, 99.00] 0.397 96.06[94.68, 97.79] 95.75[94.50, 97.52] 96.50[94.90, 98.20] 0.152 98.00[96.67, 99.25] 97.75[96.75, 99.16] 98.25[96.50, 99.25] 0.412
 PaO2/FiO2, median [Q1,Q3] 211.79[171.42, 253.23] 209.00[164.00, 253.62] 213.00[179.33, 253.06] 0.253 169.46[155.08, 182.83] 166.67[157.44, 180.60] 171.33[153.44, 187.56] 0.283 242.00[217.50, 270.23] 238.46[214.00, 267.34] 248.04[222.00, 273.98] 0.209
 Reintubation 48 h, n (%) 57(12.23) 20(8.58) 37(15.88) 0.024 24(12.63) 8(8.42) 16(16.84) 0.126 37(12.17) 15(9.87) 22(14.47) 0.293
 Reintubation 28 days, n (%) 97(20.82) 46(19.74) 51(21.89) 0.648 39(20.53) 16(16.84) 23(24.21) 0.281 67(22.04) 38(25.00) 29(19.08) 0.268
 Mortality 28 days, n (%) 22(4.72) 10(4.29) 12(5.15) 0.827 7(3.68) 3(3.16) 4(4.21) 1.000 21(6.91) 12(7.89) 9(5.92) 0.651
 Duration before reintubation, median [Q1, Q3], hours 28.65[11.57, 90.78] 73.28[21.63, 124.15] 21.52[8.84, 56.85] 0.001 25.03[9.04, 113.43] 52.22[5.96, 163.10] 21.72[10.88, 66.22] 0.424 38.55[12.12, 111.62] 73.66[27.39, 133.14] 19.70[4.62, 40.63] 0.001
 LOS in hospital, median [Q1, Q3] 11.54[7.18, 17.75] 12.62[7.65, 20.61] 10.93[6.83, 15.82] 0.001 11.87[7.65, 16.61] 12.80[7.79, 19.23] 11.28[7.48, 15.43] 0.102 12.01[7.02, 19.90] 14.59[8.68, 25.02] 10.12[6.22, 16.72]  < 0.001
 LOS in ICU, median [Q1, Q3] 5.55[3.09, 11.14] 6.36[3.85, 13.59] 4.72[2.27, 9.70]  < 0.001 5.39[3.10, 10.93] 6.22[3.82, 12.69] 4.80[2.30, 9.39] 0.026 6.19[3.12, 13.14] 7.43[4.19, 15.89] 4.25[2.23, 9.47]  < 0.001